Description

Many neurological disorders remain intractable to treatment by therapeutic agents due to the brain's natural defense: the Blood-Brain Barrier (BBB). The BBB impedes entry of virtually all molecules from blood capillaries to brain tissue; rendering thus potent neurologically active substances and drugs ineffective, simply because they cannot be delivered to where they are most needed. As a result, the BBB is the rate-limiting factor in brain drug delivery. The only truly transient, local, and non-invasive opening of the BBB under study as of now is with focused ultrasound (FUS).

The purpose of this project is to understand the mechanism, ensure the safety and efficacy, and optimize the methods of BBB opening using FUS. Ongoing studies will lead to the development of optimal parameters to induce BBB opening, performing of long term studies of this phenomena, and testing for the delivery of model drugs.

Results

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	Reversible blood-brain barrier opening using focused ultrasound Shown are horizontal consecutive slices of the brain, corresponding to contrast enhanced T1 images from day 0 (when focused ultrasound was applied) to day 3 (when closing occurred). Overlaid with red color are the voxels where the MRI contrast agent (Gd-DTPA in this case) had diffused through the BBB. The left hippocampus was not sonicated and so the contrast agent remained in the vasculature, while in the sonicated hippocampus on the right, the contrast agent diffused into the brain parenchyma until the BBB completely closed on day 3. Source: Samiotaki et al. (2012) Posted on Wednesday August 1, 2012 at 3:08 PM
	Fluorescence microscopy image of 4-5 micron DSPE-coated microbubbles The microbubbles were modified with FITC-NHS using the post-labeling technique. Source: Feshitan et al. (2012) Posted on Wednesday January 18, 2012 at 1:02 PM
	Experimental setup used to achieve non-invasive, transcranial BBB opening In this setup, the skull of the mouse is shaved but is not removed. Ultrasound is then delivered transcranially to open the BBB. Source: Vlachos et al. (2011) Posted on Wednesday April 20, 2011 at 1:04 PM
	Maximum pressure field at 500 kHz when targeting the putamen through the human skull The dashed white line denotes the contour of the putamen. Source: Deffieux & Konofagou (2010) Posted on Wednesday December 1, 2010 at 9:56 AM
	Paraffin-embedded brain sections after sonicating After sonicating the left regions at 300 kPa in the presence of 4-5 micron bubbles. The right images were used as controls. Increased fluorescence in the left images indicates the successful delivery of 3 kDa dextran molecules. Hematoxylin and eosin sections reveal no macroscopic damage. White arrows indicate erythrocytes (but may also be artifacts). Source: Choi et al. (2010) Posted on Sunday January 17, 2010 at 3:51 PM
	In vivo spatio-temporal maps of BBB opening induced with focused ultrasound Opening was assessed with sequential T1-weighted images that depicted the slow diffusion of gadolinium 13 min (red), 30 min (blue), 47 min (yellow), 65 min (green) and 82 min (cyan) after its intraperitoneal injection. Source: Choi et al. (2008) Posted on Friday July 25, 2008 at 12:50 PM

To obtain the citations for all of the publications related to this project, click here to download the complete list (in BibTeX format).

Journal Articles

	An Experimental Study on the Stiffness of Size-Isolated Microbubbles Using Atomic Force Microscopy Cherry C. Chen, Shih-Ying Wu, John D. Finan, Barclay Morrison III, Elisa E. Konofagou IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Volume 60, Number 3, Pages 524-534, March 2013 Digital Object Identifier: 10.1109/TUFFC.2013.2594 Download Full Text (PDF) | Download Citation (BibTeX)
	Ultrasound-induced blood-brain barrier opening Elisa E. Konofagou, Yao-Sheng Tung, James J. Choi, Thomas Deffieux, Jameel A. Feshitan, Mark A. Borden, Babak Baseri, Fotis Vlachos Current Pharmaceutical Biotechnology, September 2012 Invited Contribution Download Citation (BibTeX)
	Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood-brain barrier using focused ultrasound and microbubbles Babak Baseri, James J. Choi, Thomas Deffieux, Gesthimani Samiotaki, Yao-Sheng Tung, Oluyemi O. Olumolade, Scott A. Small, Barclay Morrison III, Elisa E. Konofagou Physics in Medicine and Biology, Volume 57, Number N, Pages 65-81, March 2012 Digital Object Identifier: 10.1088/0031-9155/57/7/N65 Download Full Text (PDF) | Download Citation (BibTeX)
	A quantitative pressure and microbubble-size dependence study of focused ultrasound-induced blood-brain barrier opening reversibility in vivo using MRI Gesthimani Samiotaki, Fotis Vlachos, Yao-Sheng Tung, Elisa E. Konofagou Magnetic Resonance in Medicine, Volume 67, Number 3, Pages 769-777, March 2012 Digital Object Identifier: 10.1002/mrm.23063 Download Full Text (PDF) | Download Citation (BibTeX)
	Theranostic Gd(III)-lipid microbubbles for MRI-guided focused ultrasound surgery Jameel A. Feshitan, Fotis Vlachos, S. R. Sirsi, Elisa E. Konofagou, Mark A. Borden Biomaterials, Volume 33, Number 1, Pages 247-255, January 2012 Digital Object Identifier: 10.1016/j.biomaterials.2011.09.026 Download Full Text (PDF) | Download Citation (BibTeX)
	The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in mice Yao-Sheng Tung, Fotis Vlachos, Jameel A. Feshitan, Mark A. Borden, Elisa E. Konofagou Journal of the Acoustical Society of America, Volume 130, Number 5, Pages 3059-3067, November 2011 Digital Object Identifier: 10.1121/1.3646905 Download Full Text (PDF) | Download Citation (BibTeX)
	Noninvasive and localized neuronal delivery using short ultrasonic pulses and microbubbles James J. Choi, Kirsten Selert, Fotis Vlachos, Anna Wong, Elisa E. Konofagou Proceedings of the National Academy of Sciences of the USA, Volume 108, Number 40, Pages 16539-16544, October 2011 Digital Object Identifier: 10.1073/pnas.1105116108 Download Full Text (PDF) | Download Citation (BibTeX)
	Non-invasive, transient and selective blood-brain barrier opening in non-human primates in vivo Fabrice Marquet, Yao-Sheng Tung, Tobias Teichert, Vincent P. Ferrera, Elisa E. Konofagou PLoS One, Volume 6, Number 7, e. 22598, July 2011 Digital Object Identifier: 10.1371/journal.pone.0022598 Download Full Text (PDF) | Download Citation (BibTeX)
	Permeability dependence study of the focused ultrasound-induced blood-brain barrier opening at distinct pressures and microbubble diameters using DCE-MRI Fotis Vlachos, Yao-Sheng Tung, Elisa E. Konofagou Magnetic Resonance in Medicine, Volume 66, Pages 821-830, April 2011 Digital Object Identifier: 10.1002/mrm.22848 Download Full Text (PDF) | Download Citation (BibTeX)
	Feasibility of cavitation-guided blood-brain barrier opening using FUS and microbubbles in non-human primates Yao-Sheng Tung, Fabrice Marquet, Tobias Teichert, Vincent P. Ferrera, Elisa E. Konofagou Applied Physics Letters, Volume 98, Number 16, e. 163704, April 2011 Digital Object Identifier: 10.1063/1.3580763 Download Full Text (PDF) | Download Citation (BibTeX)
	Non-invasive and localized blood-brain barrier disruption using focused ultrasound can be achieved at short pulse lengths and low pulse repetition frequencies James J. Choi, Kirsten Selert, Zimeng Gao, Gesthimani Samiotaki, Babak Baseri, Elisa E. Konofagou Journal of Cerebral Blood Flow and Metabolism, Volume 31, Number 2, Pages 725-737, February 2011 Digital Object Identifier: 10.1038/jcbfm.2010.155 Download Full Text (PDF) | Download Citation (BibTeX)
	A study of the nonlinear propagation of focused ultrasound beams through the skull by opening the blood-brain barrier Noé Jiménez, Fabrice Marquet, Francisco Camarena, Elisa E. Konofagou, Javier Redondo, Bernardino Roig, Rubén Picó Revista de Acústica, Volume 43, Number 1-2, Pages 5-11, 2011 Awarded the 2011 Andres Lara Prize by the Spanish Society of Acoustics Download Full Text (PDF) | Download Citation (BibTeX)
	Numerical study of a simple transcranial focused ultrasound system applied to blood-brain barrier opening Thomas Deffieux, Elisa E. Konofagou IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Volume 57, Number 12, Pages 2637-2653, December 2010 Digital Object Identifier: 10.1109/TUFFC.2010.1738 Download Full Text (PDF) | Download Citation (BibTeX)
	In vivo transcranial cavitation threshold detection during ultrasound-induced blood-brain barrier opening Yao-Sheng Tung, Fotis Vlachos, James J. Choi, Thomas Deffieux, Kirsten Selert, Elisa E. Konofagou Physics in Medicine and Biology, Volume 55, Number 20, Pages 6141-6155, October 2010 Digital Object Identifier: 10.1088/0031-9155/55/20/007 Download Full Text (PDF) | Download Citation (BibTeX)
	Permeability assessment of the focused ultrasound-induced blood-brain barrier opening using dynamic contrast-enhanced MRI Fotis Vlachos, Yao-Sheng Tung, Elisa E. Konofagou Physics in Medicine and Biology, Volume 55, Number 18, Pages 5451-5466, September 2010 Digital Object Identifier: 10.1088/0031-9155/55/18/012 Download Full Text (PDF) | Download Citation (BibTeX)
	Multi-modality safety assessment of blood-brain barrier opening using focused ultrasound and Definity microbubbles: a short-term study Babak Baseri, James J. Choi, Yao-Sheng Tung, Elisa E. Konofagou Ultrasound in Medicine and Biology, Volume 36, Number 9, Pages 1445-1459, September 2010 Digital Object Identifier: 10.1016/j.ultrasmedbio.2010.06.005 Download Full Text (PDF) | Download Citation (BibTeX)
	Identifying the inertial cavitation threshold and skull effects in a vessel phantom using focused ultrasound and microbubbles Yao-Sheng Tung, James J. Choi, Babak Baseri, Elisa E. Konofagou Ultrasound in Medicine and Biology, Volume 36, Number 5, Pages 840-852, May 2010 Digital Object Identifier: 10.1016/j.ultrasmedbio.2010.02.009 Download Full Text (PDF) | Download Citation (BibTeX)
	Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo James J. Choi, Shougang Wang, Yao-Sheng Tung, Barclay Morrison III, Elisa E. Konofagou Ultrasound in Medicine and Biology, Volume 36, Number 1, Pages 58-67, January 2010 Digital Object Identifier: 10.1016/j.ultrasmedbio.2009.08.006 Download Full Text (PDF) | Download Citation (BibTeX)
	Microbubble-size dependence of focused ultrasound-induced blood-brain barrier opening in mice in vivo James J. Choi, Jameel A. Feshitan, Babak Baseri, Shougang Wang, Yao-Sheng Tung, Mark A. Borden, Elisa E. Konofagou IEEE Transactions on Biomedical Engineering, Volume 57, Number 1, Pages 145-154, January 2010 Digital Object Identifier: 10.1109/TBME.2009.2034533 Download Full Text (PDF) | Download Citation (BibTeX)
	Feasibility study of a clinical blood-brain barrier opening ultrasound system Fabrice Marquet, Yao-Sheng Tung, Elisa E. Konofagou NanoLife, Volume 1, Number 3-4, Pages 309-322, 2010 Digital Object Identifier: 10.1142/S1793984410000286 Download Full Text (PDF) | Download Citation (BibTeX)
	Non-invasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound James J. Choi, Shougang Wang, Truman R. Brown, Scott A. Small, Karen E. Duff, Elisa E. Konofagou Ultrasonic Imaging, Volume 30, Number 3, Pages 189-200, July 2008 Download Full Text (PDF) | Download Citation (BibTeX)
	Spatio-temporal analysis of molecular delivery through the blood-brain barrier using focused ultrasound James J. Choi, Mathieu Pernot, Truman R. Brown, Scott A. Small, Elisa E. Konofagou Physics in Medicine and Biology, Volume 52, Number 18, Pages 5509-5530, September 2007 Digital Object Identifier: 10.1088/0031-9155/52/18/004 Download Full Text (PDF) | Download Citation (BibTeX)
	Non-invasive, transcranial, and localized opening of the blood-brain barrier in mice using focused ultrasound - a feasibility study James J. Choi, Mathieu Pernot, Scott A. Small, Elisa E. Konofagou Ultrasound in Medicine and Biology, Volume 33, Number 1, Pages 95-104, January 2007 Digital Object Identifier: 10.1016/j.ultrasmedbio.2006.07.018 Download Full Text (PDF) | Download Citation (BibTeX)

Conference Papers and Presentations

	Targeted Drug Delivery with Focused Ultrasound-Induced Blood-Brain Barrier Opening Using Acoustically-Activated Nanodroplets Cherry C. Chen, Paul S. Sheeran, Shih-Ying Wu, Oluyemi O. Olumolade, Paul S. Dayton, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Prague, Czech Republic), July 21 to 25, 2013 Download Citation (BibTeX)
	Monitoring of FUS-induced BBB opening in non-human primates using transcranial cavitation detection in vivo and the human skull effect Shih-Ying Wu, Fabrice Marquet, Yao-Sheng Tung, Tobias Teichert, Matthew E. Downs, Cherry C. Chen, Vincent P. Ferrera, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Prague, Czech Republic), July 21 to 25, 2013 Download Citation (BibTeX)
	Focused Ultrasound Induced Blood-Brain Barrier Opening in Macromolecule Delivery Shutao Wang, Oluyemi O. Olumolade, Susan Osting, Corinna Burger, Elisa E. Konofagou 13th International Symposium on Therapeutic Ultrasound (Shanghai, China), May 12 to 15, 2013 Download Citation (BibTeX)
	The cavitation-dependent zonula-occludens-1 integrity after ultrasound-induced blood-brain barrier opening Yao-Sheng Tung, Cherry C. Chen, Oluyemi O. Olumolade, Shih-Ying Wu, Shutao Wang, Elisa E. Konofagou Cold Spring Harbor Laboratory Meeting: The Blood-Brain Barrier (Cold Spring Harbor, NY, USA), December 5 to 8, 2012 Download Citation (BibTeX)
	Microbubble Distribution Dependence of Focused Ultrasound Induced Blood-Brain Barrier Opening Shutao Wang, Gesthimani Samiotaki, Jameel A. Feshitan, Oluyemi O. Olumolade, Elisa E. Konofagou Cold Spring Harbor Laboratory Meeting: The Blood-Brain Barrier (Cold Spring Harbor, NY, USA), December 5 to 8, 2012 Download Citation (BibTeX)
	Microbubble-type Dependence of Focused Ultrasound Induced Blood Brain Barrier Opening Shutao Wang, Gesthimani Samiotaki, Jameel A. Feshitan, Oluyemi O. Olumolade, Elisa E. Konofagou 3rd International Symposium on Focused Ultrasound (Bethesda, MD, USA), October 14 to 17, 2012 Download Citation (BibTeX)
	Quantification of stable cavitation dose during FUS-induced blood-brain barrier opening in mice and in non-human primates Yao-Sheng Tung, Shih-Ying Wu, Fabrice Marquet, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Dresden, Germany), October 7 to 10, 2012 Download Citation (BibTeX)
	Non-human primate skull effects on the FUS-induced blood-brain barrier opening Shih-Ying Wu, Yao-Sheng Tung, Fabrice Marquet, Cherry C. Chen, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Dresden, Germany), October 7 to 10, 2012 Download Citation (BibTeX)
	An experimental study on the apparent stiffness of size-isolated microbubbles used for blood-brain barrier opening applications Cherry C. Chen, Shih-Ying Wu, John D. Finan, Barclay Morrison III, Elisa E. Konofagou Proceedings of the IEEE International Ultrasonics Symposium (Dresden, Germany), October 7 to 10, 2012 Download Full Text (PDF) | Download Citation (BibTeX)
	An experimental study on the stiffness of size-isolated microbubbles with relevance to blood-brain barrier opening applications Cherry C. Chen, Shih-Ying Wu, John D. Finan, Barclay Morrison III, Elisa E. Konofagou Gordon Research Conference: Barriers of the Central Nervous System (New London, NH, USA), June 17 to 22, 2012 Download Citation (BibTeX)
	Physical mechanism of non-inertial cavitation induced blood-brain barrier opening using focused ultrasound and microbubbles Yao-Sheng Tung, Oluyemi O. Olumolade, Shutao Wang, Shih-Ying Wu, Elisa E. Konofagou 12th International Symposium on Therapeutic Ultrasound (Heidelberg, Germany), June 10 to 13, 2012 Download Citation (BibTeX)
	Non-human primate skull effects on the in vivo study of the mechanism of the FUS-induced blood-brain barrier opening Shih-Ying Wu, Yao-Sheng Tung, Fabrice Marquet, Elisa E. Konofagou 12th International Symposium on Therapeutic Ultrasound (Heidelberg, Germany), June 10 to 13, 2012 Download Citation (BibTeX)
	Microbubble-enhanced focused ultrasound blood-brain barrier opening in non-human primates: targeting accuracy and closing timeline Fabrice Marquet, Yao-Sheng Tung, Tobias Teichert, Vincent P. Ferrera, Elisa E. Konofagou 12th International Symposium on Therapeutic Ultrasound (Heidelberg, Germany), June 10 to 13, 2012 Download Citation (BibTeX)
	An experimental study on the stiffness of size-isolated microbubbles used for blood-brain barrier opening Cherry C. Chen, Shih-Ying Wu, John D. Finan, Barclay Morrison III, Elisa E. Konofagou Proceedings of the 12th International Symposium on Therapeutic Ultrasound (Heidelberg, Germany), June 10 to 13, 2012 Download Full Text (PDF) | Download Citation (BibTeX)
	Ultrasound-induced drug delivery through the blood-brain barrier Elisa E. Konofagou, Gesthimani Samiotaki Euroson School 2012: Ultrasound Elastography (Athens, Greece), January 21 to 22, 2012 Download Citation (BibTeX)
	Permeability and reversibility timeline study of the focused-ultrasound induced blood-brain barrier opening at distinct pressures and microbubble sizes in vivo Gesthimani Samiotaki, Fotis Vlachos, Yao-Sheng Tung, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Orlando, FL, USA), October 18 to 21, 2011 Download Citation (BibTeX)
	Mechanism monitoring of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in non-human primates Yao-Sheng Tung, Fabrice Marquet, Tobias Teichert, Vincent P. Ferrera, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Orlando, FL, USA), October 18 to 21, 2011 Download Citation (BibTeX)
	Initial in vivo feasibility of a simple pre-clinical focused ultrasound system applied to blood-brain barrier opening Fabrice Marquet, Yao-Sheng Tung, Tobias Teichert, Vincent P. Ferrera, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Orlando, FL, USA), October 18 to 21, 2011 Download Citation (BibTeX)
	Bubble dependence of the mechanism for FUS-induced blood-brain barrier opening in mice in vivo Yao-Sheng Tung, Fotis Vlachos, Kirsten Selert, Elisa E. Konofagou 161st Meeting of the Acoustical Society of America (Seattle, WA, USA), May 23 to 27, 2011 Shortlisted for the Best Student Paper Competition Download Citation (BibTeX)
	Pressure and microbubble-size dependence of the FUS-induced blood brain barrier opening reversibility in vivo Gesthimani Samiotaki, Fotis Vlachos, Yao-Sheng Tung, Elisa E. Konofagou Annual Meeting of the International Society for Magnetic Resonance in Medicine (Montreal, QC, Canada), May 7 to 13, 2011 Download Citation (BibTeX)
	In vivo identification of the mechanism behind ultrasound-induced blood-brain barrier opening Yao-Sheng Tung, Fotis Vlachos, Kirsten Selert, Elisa E. Konofagou American Institute of Ultrasound in Medicine Annual Convention (New York, NY, USA), April 14 to 17, 2011 Download Citation (BibTeX)
	Feasibility of a simple transcranial focused ultrasound system for blood-brain barrier opening Fabrice Marquet, Yao-Sheng Tung, Fotis Vlachos, Elisa E. Konofagou American Institute of Ultrasound in Medicine Annual Convention (New York, NY, USA), April 14 to 17, 2011 Download Citation (BibTeX)
	The bubble-dependent mechanism of FUS-induced blood-brain barrier opening in mice in vivo Yao-Sheng Tung, Fotis Vlachos, Jameel A. Feshitan, Mark A. Borden, Elisa E. Konofagou 11th International Symposium on Therapeutic Ultrasound (New York, NY, USA), April 11 to 13, 2011 Winner of the Best Student Paper Competition Download Citation (BibTeX)
	Pressure and microbubble size dependence study of focused ultrasound-induced blood-brain barrier opening reversibility in vivo Gesthimani Samiotaki, Fotis Vlachos, Yao-Sheng Tung, Elisa E. Konofagou 11th International Symposium on Therapeutic Ultrasound (New York, NY, USA), April 11 to 13, 2011 Download Citation (BibTeX)
	Numerical study of nonlinear, transcranial focused ultrasound wave propagation for Blood-Brain Barrier (BBB) opening Noé Jiménez, Bernardino Roig, Javier Redondo, Rubén Picó, Fabrice Marquet, Elisa E. Konofagou, Francisco Camarena 11th International Symposium on Therapeutic Ultrasound (New York, NY, USA), April 11 to 13, 2011 Download Citation (BibTeX)
	Nonlinear effects in the radiation force generated by amplitude-modulated focused beams N. González, Noé Jiménez, Javier Redondo, Bernardino Roig, Rubén Picó, V. Sánchez-Morcillo, Elisa E. Konofagou, Francisco Camarena 11th International Symposium on Therapeutic Ultrasound (New York, NY, USA), April 11 to 13, 2011 Download Citation (BibTeX)
	Feasibility of a single-element transcranial focused ultrasound system for blood-brain barrier opening Fabrice Marquet, Yao-Sheng Tung, Fotis Vlachos, Elisa E. Konofagou 11th International Symposium on Therapeutic Ultrasound (New York, NY, USA), April 11 to 13, 2011 Download Citation (BibTeX)
	In-vivo quantitative permeability assessment of the focused-ultrasound-induced blood-brain barrier opening using dynamic contrast-enhanced MRI Fotis Vlachos, Yao-Sheng Tung, Elisa E. Konofagou IEEE International Ultrasonics Symposium (San Diego, CA, USA), October 11 to 14, 2010 Download Citation (BibTeX)
	In vivo transcranial cavitation detection during ultrasound-induced blood-brain barrier opening Yao-Sheng Tung, Fotis Vlachos, Thomas Deffieux, James J. Choi, Kirsten Selert, Elisa E. Konofagou IEEE International Ultrasonics Symposium (San Diego, CA, USA), October 11 to 14, 2010 Shortlisted for the Best Student Paper Competition Download Citation (BibTeX)
	MR-based pharmacokinetics of the focused-ultrasound-induced blood-brain barrier Opening Fotis Vlachos, Yao-Sheng Tung, Elisa E. Konofagou Biomedical Engineering Society Annual Meeting (Austin, TX, USA), October 6 to 9, 2010 Download Citation (BibTeX)
	Noninvasive in vivo cavitation threshold detection during blood-brain barrier opening using focused ultrasound and Definity Yao-Sheng Tung, Fotis Vlachos, Thomas Deffieux, James J. Choi, Elisa E. Konofagou 159th Meeting of the Acoustical Society of America (Baltimore, MD, USA), April 19 to 23, 2010 Download Citation (BibTeX)
	Quantitative assessment of in vivo focused ultrasound induced blood-brain barrier opening using Magnetic Resonance Imaging Gesthimani Samiotaki, Fotis Vlachos, Yao-Sheng Tung, Elisa E. Konofagou Northeast Bioengineering Conference (New York, NY, USA), March 26 to 28, 2010 Download Citation (BibTeX)
	Identifying the skull effects to the inertial cavitation threshold of microbubbles in a vessel phantom Yao-Sheng Tung, James J. Choi, Elisa E. Konofagou Northeast Bioengineering Conference (New York, NY, USA), March 26 to 28, 2010 Download Citation (BibTeX)
	Delivery of pharmacologically-relevant sized molecules through the ultrasound-induced blood-brain barrier opening in vivo James J. Choi, Shougang Wang, Yao-Sheng Tung, Babak Baseri, Barclay Morrison III, Elisa E. Konofagou Neuroscience (Chicago, IL, USA), October 17 to 21, 2009 Download Citation (BibTeX)
	Mechanism and safety of FUS-induced BBB opening Elisa E. Konofagou, James J. Choi, Babak Baseri, Yao-Sheng Tung 9th International Symposium on Therapeutic Ultrasound (Aix-en-Provence, France), September 23 to 26, 2009 Download Citation (BibTeX)
	Identifying the inertial cavitation threshold of monodispersed microbubbles and skull effects in a vessel phantom using focused ultrasound Yao-Sheng Tung, James J. Choi, Elisa E. Konofagou 9th International Symposium on Therapeutic Ultrasound (Aix-en-Provence, France), September 23 to 26, 2009 Download Citation (BibTeX)
	Brain region and microbubble-size dependence of the focused ultrasound-induced blood-brain barrier opening in mice in vivo James J. Choi, Jameel A. Feshitan, Babak Baseri, Shougang Wang, Yao-Sheng Tung, Mark A. Borden, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Rome, Italy), September 18 to 21, 2009 Download Citation (BibTeX)
	Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's APP/PS1 mice using focused ultrasound James J. Choi, Shougang Wang, A. Lee, Truman R. Brown, Scott A. Small, Karen E. Duff, Elisa E. Konofagou Neuroscience (Washington, DC, USA), November 15 to 19, 2008 Download Citation (BibTeX)
	Qualitative and quantitative analysis of the molecular delivery through the ultrasound-enhanced blood-brain barrier opening in the murine brain Shougang Wang, James J. Choi, Yao-Sheng Tung, Barclay Morrison III, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Beijing, China), November 2 to 5, 2008 Download Citation (BibTeX)
	The dependence of the ultrasound-induced blood-brain barrier opening characteristics on microbubble size in vivo James J. Choi, Jameel A. Feshitan, Shougang Wang, Yao-Sheng Tung, Babak Baseri, Mark A. Borden, Elisa E. Konofagou 8th International Symposium on Therapeutic Ultrasound (Minneapolis, MN, USA), September 10 to 13, 2008 Download Citation (BibTeX)
	Qualitative and quantitative analysis of molecular delivery through the ultrasound-induced blood-brain barrier opening in mice Shougang Wang, Babak Baseri, James J. Choi, Yao-Sheng Tung, Barclay Morrison III, Elisa E. Konofagou 8th International Symposium on Therapeutic Ultrasound (Minneapolis, MN, USA), September 10 to 13, 2008 Download Citation (BibTeX)
	Characterization and optimization of trans-blood-brain barrier diffusion in vivo Elisa E. Konofagou, James J. Choi, Babak Baseri, A. Lee 8th International Symposium on Therapeutic Ultrasound (Minneapolis, MN, USA), September 10 to 13, 2008 Download Citation (BibTeX)
	Trans-blood-brain barrier delivery of compounds at pharmacologically relevant molecular weights in the hippocampus of mice using focused ultrasound James J. Choi, Shougang Wang, Yao-Sheng Tung, Barclay Morrison III, Elisa E. Konofagou 155th Meeting of the Acoustical Society of America (Paris, France), June 29 to July 4, 2008 Download Citation (BibTeX)
	Identifying the inertial cavitation threshold in a vessel phantom using FUS and microbubbles Yao-Sheng Tung, James J. Choi, Shougang Wang, Jameel A. Feshitan, Mark A. Borden, Elisa E. Konofagou 155th Meeting of the Acoustical Society of America (Paris, France), June 29 to July 4, 2008 Download Citation (BibTeX)
	Molecular delivery and microbubble dependence study of the FUS-induced blood-brain barrier opening in vivo James J. Choi, Shougang Wang, Barclay Morrison III, Elisa E. Konofagou IEEE International Ultrasonics Symposium (New York, NY, USA), October 28 to 31, 2007 Download Citation (BibTeX)
	Focused ultrasound-induced molecular delivery through the blood-brain barrier James J. Choi, Shougang Wang, Barclay Morrison III, Elisa E. Konofagou Proceedings of the IEEE International Ultrasonics Symposium (New York, NY, USA), October 28 to 31, 2007 Download Full Text (PDF) | Download Citation (BibTeX)
	Non-invasive opening of the blood-brain barrier using focused ultrasound in mice James J. Choi, Scott A. Small, Truman R. Brown, Elisa E. Konofagou Annual Meeting of the International Society for Magnetic Resonance in Medicine (Berlin, Germany), May 19 to 25, 2007 Download Citation (BibTeX)
	Non-invasive generation and monitoring of ultrasound-induced blood-brain barrier opening in the murine hippocampus James J. Choi, Scott A. Small, Truman R. Brown, Elisa E. Konofagou Annual Meeting of the International Society for Magnetic Resonance in Medicine (Berlin, Germany), May 19 to 25, 2007 Download Citation (BibTeX)
	Noninvasive and reversible opening of the blood-brain barrier using focused ultrasound Elisa E. Konofagou, James J. Choi Leading Edge Symposium (Atlantic City, NJ, USA), May 3, 2007 Invited Contribution Download Citation (BibTeX)
	Optimization of ultrasound-induced transient blood-brain barrier opening in mice James J. Choi, Scott A. Small, Elisa E. Konofagou Proceedings of the IEEE International Ultrasonics Symposium (Vancouver, BC, Canada), October 2 to 5, 2006 Download Full Text (PDF) | Download Citation (BibTeX)
	Focused ultrasound-induced opening of the blood-brain barrier in mice James J. Choi, Elisa E. Konofagou 151st Acoustical Society of America Meeting (Providence, RI, USA), June 5 to 9, 2006 Download Citation (BibTeX)
	Feasibility of treatment of neurodegenerative diseases through ultrasound-induced blood-brain barrier opening in vivo James J. Choi, Mathieu Pernot, Scott A. Small, Elisa E. Konofagou American Institute of Ultrasound in Medicine Annual Convention (Washington, DC, USA), March 23 to 26, 2006 AIUM New Investigator Award Download Citation (BibTeX)
	Noninvasive blood-brain barrier opening in live mice James J. Choi, Mathieu Pernot, Scott A. Small, Elisa E. Konofagou Proceedings of the 5th International Symposium on Therapeutic Ultrasound (Boston, MA, USA), October 27 to 29, 2005 Download Full Text (PDF) | Download Citation (BibTeX)
	Feasibility of transcranial, localized drug-delivery in the brain of Alzheimer's-model mice using focused ultrasound James J. Choi, Mathieu Pernot, Scott A. Small, Elisa E. Konofagou Proceedings of the IEEE International Ultrasonics Symposium (Rotterdam, The Netherlands), September 17 to 20, 2005 Download Full Text (PDF) | Download Citation (BibTeX)

Thesis

Noninvasive, localized, and transient brain drug delivery using focused ultrasound and microbubbles James J. Choi Ph.D. Thesis, Columbia University (New York, NY, USA), 2010 Download Full Text (PDF) | Download Citation (BibTeX)

Article in the Popular Press

The brain: maybe you do need a hole in your head, to let the medicine in Article in Discover Magazine on November 15, 2011 Link: http://discovermagazine.com/2011/nov/10-the-brain-maybe-do-need-hole-head-let-medicine-in Download Citation (BibTeX)

The researchers involved in this project are listed below.

Principal Investigator

Elisa Konofagou, Ph.D. Email: ek2191 [at] columbia [dot] edu Phone: +1 212 342 0863 Office: PS19-418A View Profile | View Publications

Postdoctoral Research Scientists

	Cherry Chen, Ph.D. Email: ccc2136 [at] columbia [dot] edu Phone: +1 212 342 1612 Office: PS19-407 View Profile | View Publications
	Shutao Wang, Ph.D. Email: sw2735 [at] columbia [dot] edu Phone: +1 212 342 1612 Office: PS19-407 View Profile | View Publications

Ph.D. Students

	Gesthimani Samiotaki, B.S. Email: gs2496 [at] columbia [dot] edu Phone: +1 212 342 1612 Office: PS19-405 View Profile | View Publications
	Shih-Ying Wu, M.S. Email: sw2709 [at] columbia [dot] edu Phone: +1 212 342 1612 Office: PS19-405 View Profile | View Publications

Research Associates

	Oluyemi Olumolade, B.S. Email: ooo2113 [at] columbia [dot] edu Phone: +1 212 342 1612 Office: PS19-405 View Profile | View Publications
	Anushree Srivastava, M.S. Email: as4413 [at] columbia [dot] edu Phone: +1 212 342 1612 Office: PS19-407 View Profile | View Publications