Description

Palpation is routinely used by physicians to distinguish cancerous tissues from normal tissues in organs such as the breast and the prostate. This technique is effective because cancerous tissues typically have higher tissue stiffness characteristic compared to normal soft tissues. However, the palpation technique is unable to detect abnormalities deep within tissue, for example, liver.

Here, we introduce the application of the Harmonic Motion Imaging (HMI) technique that induces dynamic tissue vibrations internally for tissue elasticity characterization. Moreover, the HMI technique can monitor changes in tissues elasticity real-time during focused ultrasound surgery (FUS). Thus, physicians can interrupt the FUS treatment when it is necessary. The advantages of this technique are detecting cancerous tissues early and treating them non-invasively.

Results

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	M-mode of a tumor during ablation with HMIFU Overlaid on the M-mode are color-coded HMI displacement amplitudes during heating (blue for negative, red for positive). Source: Maleke & Konofagou (2010) Posted on Sunday February 14, 2010 at 10:32 AM
	Histology images of an ablated tumor The left image shows nonablated tumor cells; the white arrows denote red blood cells. The right image shows an ablated mammary tumor, in which damaged and necrotic cells are indicated by hemorrhagic regions (white arrows) and fine fibrous strands outlined by adipose tissue (white lobes). Source: Maleke & Konofagou (2010) Posted on Saturday January 23, 2010 at 4:36 PM
	An axisymmetric model used for HMI simulations Shown are the dimensions of the model, the mesh, the location of the focal region, and an example of a shear waves propagating out of the focal region. Source: Vappou et al. (2009) Posted on Wednesday June 10, 2009 at 12:29 PM
	Gross pathology of canine liver tissue after HIFU ablation The white-colored tissue is indicative of blanching caused by HIFU-induced heating. Source: Maleke & Konofagou (2008) Posted on Monday March 17, 2008 at 11:26 AM

To obtain the citations for all of the publications related to this project, click here to download the complete list (in BibTeX format).

Journal Articles

	Harmonic Motion Imaging (HMI) for tumor imaging and treatment monitoring Elisa E. Konofagou, Caroline Maleke, Jonathan Vappou Current Medical Imaging Reviews, Volume 8, Number 1, Pages 16-26, February 2012 Download Full Text (PDF) | Download Citation (BibTeX)
	Performance assessment of HIFU lesion detection by Harmonic Motion Imaging for Focused Ultrasound (HMIFU): a 3-D finite-element-based framework with experimental validation Yi Hou, Jianwen Luo, Fabrice Marquet, Caroline Maleke, Jonathan Vappou, Elisa E. Konofagou Ultrasound in Medicine and Biology, Volume 37, Number 12, Pages 2013-2017, December 2011 Digital Object Identifier: 10.1016/j.ultrasmedbio.2011.09.005 Download Full Text (PDF) | Download Citation (BibTeX)
	Simulation study of Amplitude-Modulated (AM) Harmonic Motion Imaging (HMI) for stiffness contrast quantification with experimental validation Caroline Maleke, Jianwen Luo, Viktor Gamarnik, Xin L. Lu, Elisa E. Konofagou Ultrasonic Imaging, Volume 32, Number 6, Pages 154-176, July 2010 Download Full Text (PDF) | Download Citation (BibTeX)
	In vivo feasibility of real-time monitoring of Focused Ultrasound Surgery (FUS) using Harmonic Motion Imaging (HMI) Caroline Maleke, Elisa E. Konofagou IEEE Transactions on Biomedical Engineering, Volume 57, Number 1, Pages 7-11, January 2010 Digital Object Identifier: 10.1109/TBME.2009.2027423 Download Full Text (PDF) | Download Citation (BibTeX)
	Quantitative viscoelastic parameters measured by harmonic motion imaging Jonathan Vappou, Caroline Maleke, Elisa E. Konofagou Physics in Medicine and Biology, Volume 54, Number 11, Pages 3579-3595, June 2009 Digital Object Identifier: 10.1088/0031-9155/54/11/020 Download Full Text (PDF) | Download Citation (BibTeX)
	Harmonic Motion Imaging for Focused Ultrasound (HMIFU): a fully integrated technique for sonication and monitoring of thermal ablation in tissues Caroline Maleke, Elisa E. Konofagou Physics in Medicine and Biology, Volume 53, Number 6, Pages 1773-1793, March 2008 Digital Object Identifier: 10.1088/0031-9155/53/6/018 Download Full Text (PDF) | Download Citation (BibTeX)
	Single-element focused transducer method for harmonic motion imaging Caroline Maleke, Mathieu Pernot, Elisa E. Konofagou Ultrasonic Imaging, Volume 28, Number 3, Pages 144-158, July 2006 Download Full Text (PDF) | Download Citation (BibTeX)

Conference Papers and Presentations

	Real-time 2-D elasticity imaging and monitoring of HIFU treatment using Harmonic Motion Imaging for focused Ultrasound (HMIFU) Yi Hou, Jean Provost, Julien L. Grondin, Shutao Wang, Fabrice Marquet, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Prague, Czech Republic), July 21 to 25, 2013 Download Citation (BibTeX)
	Optimization of Real-Time Acoustical and Mechanical Monitoring of High Intensity Focused Ultrasound (HIFU) treatment using Harmonic Motion Imaging for High Focused Ultrasound (HMIFU) Yi Hou, Fabrice Marquet, Shutao Wang, Elisa E. Konofagou 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Osaka, Japan), July 3 to 7, 2013 Download Citation (BibTeX)
	A Viscoelastic Property Study in Canine Liver Before and After HIFU Ablation In Vitro Danial Shahmirzadi, Jiangang Chen, Yi Hou, Elisa E. Konofagou 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Osaka, Japan), July 3 to 7, 2013 Download Full Text (PDF) | Download Citation (BibTeX)
	Mechanical and acoustical monitoring during HIFU treatment using Harmonic Motion Imaging for Focused Ultrasound (HMIFU) ex vivo Yi Hou, Fabrice Marquet, Shutao Wang, Elisa E. Konofagou 13th International Symposium on Therapeutic Ultrasound (Shanghai, China), May 12 to 15, 2013 Download Citation (BibTeX)
	HIFU beam localization using Harmonic Motion Imaging Yang Han, Yi Hou, Shutao Wang, Elisa E. Konofagou 13th International Symposium on Therapeutic Ultrasound (Shanghai, China), May 12 to 15, 2013 Download Full Text (PDF) | Download Citation (BibTeX)
	Potential strong-HIFU-ablation-induced tissue damage as measured by viscoelastic characterization of canine liver tissue post-ablation Danial Shahmirzadi, Yi Hou, Elisa E. Konofagou American Institute of Ultrasound in Medicine Annual Convention (New York, NY, USA), April 6 to 10, 2013 Download Full Text (PDF) | Download Citation (BibTeX)
	Viscoelastic mechanical properties of the canine liver before and after focused ultrasound-induced thermal ablation in vitro Danial Shahmirzadi, Yi Hou, Elisa E. Konofagou Biomedical Engineering Society Annual Meeting (Atlanta, GA, USA), October 24 to 27, 2012 Download Full Text (PDF) | Download Citation (BibTeX)
	Radiation-force-based estimation of acoustic attenuation using harmonic motion imaging Jiangang Chen, Yi Hou, Fabrice Marquet, Elisa E. Konofagou 164th Meeting of the Acoustical Society of America (Kansas City, MO, USA), October 22 to 26, 2012 Download Citation (BibTeX)
	Multi-parametric monitoring of viscoelastic property changes during HIFU ablation of canine liver ex vivo using HMIFU with preliminary validation Yi Hou, Danial Shahmirzadi, Fabrice Marquet, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Dresden, Germany), October 7 to 10, 2012 Download Citation (BibTeX)
	Viscoelasticity parameters of HIFU ablated canine liver tissues ex vivo Danial Shahmirzadi, Yi Hou, Elisa E. Konofagou 11th International Tissue Elasticity Conference (Deauville, France), October 2 to 5, 2012 Download Full Text (PDF) | Download Citation (BibTeX)
	Multi-parametric monitoring of viscoelastic property changes during HIFU treatment using HMIFU ex vivo Yi Hou, Danial Shahmirzadi, Fabrice Marquet, Elisa E. Konofagou 11th International Tissue Elasticity Conference (Deauville, France), October 2 to 5, 2012 Download Citation (BibTeX)
	Harmonic Motion Imaging (HMI) for Focused Ultrasound (HMIFU): initial in vivo results Caroline Maleke, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Rome, Italy), September 18 to 21, 2009 Download Citation (BibTeX)
	Dynamic viscoelastic properties of soft tissues measured by Harmonic Motion Imaging (HMI): preliminary results obtained on normal and cancerous breast tissues Jonathan Vappou, Caroline Maleke, Elisa E. Konofagou 8th International Tissue Elasticity Conference (Vlissingen, Zeeland, The Netherlands), September 14 to 17, 2009 Download Citation (BibTeX)
	A Harmonic Motion Imaging- based technique for non-contact mapping and estimating regional viscoelastic properties Caroline Maleke, Jonathan Vappou, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Beijing, China), November 2 to 5, 2008 Download Citation (BibTeX)
	Harmonic Motion Imaging (HMI) compared to rotational rheometry for the measurement of soft tissue's viscoelasticity Jonathan Vappou, Caroline Maleke, Jianwen Luo, Elisa E. Konofagou 7th International Tissue Elasticity Conference (Austin, TX, USA), October 27 to 30, 2008 Download Citation (BibTeX)
	Real-time HIFU monitoring using Harmonic Motion Imaging (HMI) Caroline Maleke, Elisa E. Konofagou 8th International Symposium on Therapeutic Ultrasound (Minneapolis, MN, USA), September 10 to 13, 2008 Download Citation (BibTeX)
	Mapping of regional cancerous tissue mechanical property changes using harmonic motion imaging Caroline Maleke, Jianwen Luo, A. Pelegri, Elisa E. Konofagou ASME International Mechanical Engineering Congress and Exposition (Seattle, WA, USA), November 11 to 15, 2007 Download Citation (BibTeX)
	2D simulation of Amplitude-Modulated Harmonic Motion Imaging (AM-HMI) with experimental validation Caroline Maleke, Jianwen Luo, Elisa E. Konofagou Proceedings of the IEEE International Ultrasonics Symposium (New York, NY, USA), October 28 to 31, 2007 Download Full Text (PDF) | Download Citation (BibTeX)
	Early tumor detection and treatment guidance in breast and liver with harmonic motion imaging Caroline Maleke, Elisa E. Konofagou International Congress on Ultrasonics (Vienna, Austria), April 9 to 12, 2007 Invited Contribution Download Citation (BibTeX)
	An all-ultrasound system for sonication and real-time monitoring of temperature and ablation Caroline Maleke, Elisa E. Konofagou Proceedings of the IEEE International Ultrasonics Symposium (Vancouver, BC, Canada), October 2 to 5, 2006 Download Full Text (PDF) | Download Citation (BibTeX)
	An all-ultrasound-based system for real-time monitoring and sonication of temperature change and ablation Caroline Maleke, Elisa E. Konofagou Proceedings of the 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (New York, NY, USA), August 30 to September 3, 2006 Download Full Text (PDF) | Download Citation (BibTeX)
	An amplitude-modulated harmonic imaging method for mapping tissue ablation Caroline Maleke, Elisa E. Konofagou 151st Acoustical Society of America Meeting (Providence, RI, USA), June 5 to 9, 2006 Download Citation (BibTeX)
	Real-time monitoring of regional tissue elasticity during FUS focused ultrasound therapy using harmonic motion imaging Caroline Maleke, Mathieu Pernot, Elisa E. Konofagou Proceedings of the 5th International Symposium on Therapeutic Ultrasound (Boston, MA, USA), October 27 to 29, 2005 Download Full Text (PDF) | Download Citation (BibTeX)
	In vitro demonstration of real time monitoring of regional tissue elasticity during focused ultrasound therapy using harmonic motion imaging Caroline Maleke, Mathieu Pernot, Elisa E. Konofagou 4th International Tissue Elasticity Conference (Austin, TX, USA), October 17 to 20, 2005 Download Citation (BibTeX)
	A single-element focused transducer method for harmonic motion imaging Caroline Maleke, Mathieu Pernot, Elisa E. Konofagou Proceedings of the IEEE International Ultrasonics Symposium (Rotterdam, The Netherlands), September 17 to 20, 2005 Download Full Text (PDF) | Download Citation (BibTeX)
	Imaging localized viscoelastic properties using harmonic motion imaging Elisa E. Konofagou, Timothy P. Harrigan 3rd International Tissue Elasticity Conference (Windermere, Cumbria, UK), October 17 to 20, 2004 Download Citation (BibTeX)
	Harmonic motion imaging: applications in the detection of stiffer masses Elisa E. Konofagou, Mark Ottensmeyer, Steven L. Dawson, Kullervo Hynynen Proceedings of the IEEE International Ultrasonics Symposium (Honolulu, HI, USA), October 5 to 8, 2003 Download Full Text (PDF) | Download Citation (BibTeX)
	Estimating localized oscillatory tissue motion for assessment of the underlying mechanical modulus Elisa E. Konofagou, Kullervo Hynynen Ultrasonics International (Granada, Andalusia, Spain), July 1 to 3, 2003 Download Citation (BibTeX)
	Harmonic motion imaging: a new method for localized estimation of tissue mechanical properties Elisa E. Konofagou, Kullervo Hynynen American Institute of Ultrasound in Medicine Annual Convention (Montreal, QC, Canada), June 6 to 9, 2003 Download Citation (BibTeX)
	Harmonic motion imaging: a new method for the estimation of localized oscillatory response and modulus Elisa E. Konofagou, Kullervo Hynynen IEEE SPIE Medical Imaging Conference (San Diego, CA, USA), February 20 to 23, 2003 Download Citation (BibTeX)
	Harmonic motion imaging: a new method for the estimation of localized oscillatory response and modulus Elisa E. Konofagou, Kullervo Hynynen 1st International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity (Niagara Falls, ON, Canada), October 20 to 23, 2002 Download Citation (BibTeX)
	Localized harmonic motion imaging: theory, simulations and experiments Elisa E. Konofagou, Kullervo Hynynen Proceedings of the IEEE International Ultrasonics Symposium (Munich, Germany), October 7 to 10, 2002 Download Full Text (PDF) | Download Citation (BibTeX)

Thesis

In vivo detection and thermal treatment monitoring of breast tumors using Harmonic Motion Imaging (HMI) Caroline Maleke Ph.D. Thesis, Columbia University (New York, NY, USA), 2010 Download Full Text (PDF) | Download Citation (BibTeX)

Book Chapter

Harmonic motion imaging in HIFU monitoring Elisa E. Konofagou, Caroline Maleke Chapter 7 of Biomedical applications of vibration and acoustics in imaging and characterizations (ASME Press, New York, NY, USA), 2008 Download Citation (BibTeX)

The researchers involved in this project are listed below.

Principal Investigator

Elisa Konofagou, Ph.D. Email: ek2191 [at] columbia [dot] edu Phone: +1 212 342 0863 Office: PS19-418A View Profile | View Publications

Postdoctoral Research Scientists

	Sacha Nandlall, D.Phil. Email: sn2480 [at] columbia [dot] edu Phone: +1 212 342 1611 Office: PS19-405 View Profile | View Publications
	Danial Shahmirzadi, Ph.D. Email: ds3031 [at] columbia [dot] edu Phone: +1 212 342 1611 Office: PS19-405 View Profile | View Publications
	Shutao Wang, Ph.D. Email: sw2735 [at] columbia [dot] edu Phone: +1 212 342 1612 Office: PS19-407 View Profile | View Publications

Ph.D. Student

Yi Hou, B.S. Email: yh2367 [at] columbia [dot] edu Phone: +1 212 342 1612 Office: PS19-405 View Profile | View Publications