Description

Pulse waves are flow velocity, pressure, and diameter waves generated by ventricular ejection. Their propagation speeds and patterns are related to the vascular mechanical properties (e.g., arterial stiffness). Because of the limitation of temporal and spatial resolution, the widely-used foot-to-foot method measures the average value of the pulse-wave velocity (PWV) between two points with a long distance apart (>10 cm), instead of the regional value. However, mechanical properties are nonuniform along the arteries and diseases are typically regional.

Because of the high temporal and spatial resolution, this state-of-the-art technique may allow early detection and non-invasive mapping of vascular diseases, which may decrease mortality among high-risk patients.

Results

Click on an image to view it at full scale.

	An example of pulse wave propagation in a human aorta In this case, the pulse wave is travelling from right to left. Source: Vappou et al. (2010) Posted on Thursday January 5, 2012 at 11:03 PM
	Wall velocity and blood velocity in an aneurysm These images were taken during the systolic phase of the cardiac cycle. Source: () Posted on Monday June 13, 2011 at 1:29 PM
	B-mode image with overlaid pulse wave displacements This example was taken from the abdominal aorta of a mouse in the systolic phase of the cardiac cycle. Source: Danpinid et al. (2010) Posted on Wednesday June 2, 2010 at 1:23 PM
	Example of pulse wave propagation Successive pulse wave displacement frames, overlaid onto underlying B-mode image. In this example, the pulse wave is travelling from left to right. The white arrows depict the approximate location of foot of the wave. Source: Vappou et al. (2010) Posted on Wednesday April 7, 2010 at 1:10 PM
	Pulse wave velocity estimation The graph shows a spatiotemporal plot of pulse wave propagation in a normal aorta. From this, the pulse wave velocity can be estimated using linear regression. Source: Luo et al. (2009) Posted on Thursday April 9, 2009 at 1:06 PM

To obtain the citations for all of the publications related to this project, click here to download the complete list (in BibTeX format).

Journal Articles

	Pulse Wave Imaging (PWI) in normal, hypertensive and aneurysmal human aortas in vivo: a feasibility study Ronny X. Li, Jianwen Luo, Sandhya K. Balaram, Farooq A. Chaudhry, Danial Shahmirzadi, Elisa E. Konofagou Physics in Medicine and Biology (in press) Download Citation (BibTeX)
	Mapping the longitudinal wall stiffness heterogeneities within intact canine aortas using Pulse Wave Imaging (PWI) ex vivo Danial Shahmirzadi, Prathyush Narayanan, Ronny X. Li, William W. Qaqish, Elisa E. Konofagou Journal of Biomechanics (in press) Digital Object Identifier: 10.1016/j.jbiomech.2013.04.019 Download Full Text (PDF) | Download Citation (BibTeX)
	Pulse-wave propagation in straight-geometry vessels for stiffness estimation: theory, simulations, phantoms and in vitro findings Danial Shahmirzadi, Ronny X. Li, Elisa E. Konofagou Journal of Biomechanical Engineering, Volume 134, Number 11, Pages 1145021-1145026, November 2012 Digital Object Identifier: 10.1115/1.4007747 Download Full Text (PDF) | Download Citation (BibTeX)
	Detection of aortic wall inclusions using regional pulse wave propagation and velocity in silico Danial Shahmirzadi, Elisa E. Konofagou Artery Research, Volume 6, Number 3, Pages 114-123, September 2012 Digital Object Identifier: 10.1016/j.artres.2012.05.004 Download Full Text (PDF) | Download Citation (BibTeX)
	Arterial stiffness identification of the human carotid artery using the stress-strain relationship in vivo Tipapon Khamdaeng, Jianwen Luo, Jonathan Vappou, Pradit Terdtoon, Elisa E. Konofagou Ultrasonics, Volume 52, Number 3, Pages 402-411, March 2012 Digital Object Identifier: 10.1016/j.ultras.2011.09.006 Download Full Text (PDF) | Download Citation (BibTeX)
	Pulse wave imaging of the human carotid artery: an in vivo feasibility study Jianwen Luo, Ronny X. Li, Elisa E. Konofagou IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Volume 59, Number 1, Pages 174-181, January 2012 Download Full Text (PDF) | Download Citation (BibTeX)
	Non-invasive measurement of local pulse pressure by pulse-wave-based ultrasound manometry (PWUM) Jonathan Vappou, Jianwen Luo, Kazue Okajima, Marco di Tullio, Elisa E. Konofagou Physiological Measurement, Volume 32, Number 10, Pages 1653-1662, October 2011 Digital Object Identifier: 10.1088/0967-3334/32/10/012 Download Full Text (PDF) | Download Citation (BibTeX)
	Imaging of wall motion coupled with blood flow velocity in the heart and vessels in vivo: a feasibility study Jianwen Luo, Elisa E. Konofagou Ultrasound in Medicine and Biology, Volume 37, Number 6, Pages 980-995, June 2011 Digital Object Identifier: 10.1016/j.ultrasmedbio.2011.03.004 Download Full Text (PDF) | Download Citation (BibTeX)
	Aortic pulse wave velocity measured by pulse wave imaging (PWI): a comparison with applanation tonometry Jonathan Vappou, Jianwen Luo, Kazue Okajima, Marco di Tullio, Elisa E. Konofagou Artery Research, Volume 5, Number 2, Pages 65-71, June 2011 Digital Object Identifier: 10.1016/j.artres.2011.03.002 Download Full Text (PDF) | Download Citation (BibTeX)
	In vivo characterization of the aortic wall stress-strain relationship Asawinee Danpinid, Jianwen Luo, Jonathan Vappou, Pradit Terdtoon, Elisa E. Konofagou Ultrasonics, Volume 50, Number 7, Pages 654-665, June 2010 Digital Object Identifier: 10.1016/j.ultras.2010.01.003 Download Full Text (PDF) | Download Citation (BibTeX)
	A fast normalized cross-correlation calculation method for motion estimation Jianwen Luo, Elisa E. Konofagou IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Volume 57, Number 6, Pages 1347-1357, June 2010 Digital Object Identifier: 10.1109/TUFFC.2010.1554 Download Full Text (PDF) | Download Citation (BibTeX)
	Pulse wave imaging for non-invasive and quantitative measurement of arterial stiffness in vivo Jonathan Vappou, Jianwen Luo, Elisa E. Konofagou American Journal of Hypertension, Volume 23, Number 4, Pages 393-398, April 2010 Digital Object Identifier: 10.1038/ajh.2009.272 Download Full Text (PDF) | Download Citation (BibTeX)
	Pulse wave imaging of normal and aneurysmal abdominal aortas in vivo Jianwen Luo, Kana Fujikura, Leslie S. Tyrie, M. David Tilson III, Elisa E. Konofagou IEEE Transactions on Medical Imaging, Volume 28, Number 4, Pages 477-486, April 2009 Digital Object Identifier: 10.1109/TMI.2008.928179 Download Full Text (PDF) | Download Citation (BibTeX)
	Challenges in atherosclerotic plaque characterization with Intravascular Ultrasound (IVUS): from data collection to classification Amin Katouzian, Babak Baseri, Elisa E. Konofagou, Stéphane G. Carlier IEEE Transactions on Information Technology in Biomedicine, Volume 12, Number 3, Pages 315-327, May 2008 Digital Object Identifier: 10.1109/TITB.2007.912352 Download Full Text (PDF) | Download Citation (BibTeX)
	ECG-gated, mechanical and electromechanical wave imaging of cardiovascular tissues in vivo Mathieu Pernot, Kana Fujikura, Simon D. Fung-Kee-Fung, Elisa E. Konofagou Ultrasound in Medicine and Biology, Volume 33, Number 7, Pages 1075-1085, July 2007 Digital Object Identifier: 10.1016/j.ultrasmedbio.2007.02.003 Download Full Text (PDF) | Download Citation (BibTeX)
	A novel, non-invasive technique for pulse-wave imaging and characterization of clinically significant vascular mechanical properties in vivo Kana Fujikura, Jianwen Luo, Viktor Gamarnik, Mathieu Pernot, Royd Fukumoto, M. David Tilson III, Elisa E. Konofagou Ultrasonic Imaging, Volume 29, Number 3, Pages 137-154, July 2007 Download Full Text (PDF) | Download Citation (BibTeX)

Conference Papers and Presentations

	Noninvasive arterial pulse pressure mapping using Pulse Wave Ultrasound Manometry (PWUM) in hypertensive aortas and stenotic carotid arteries in vivo Ronny X. Li, Isaac Jourard, Joyce Salomon, Prathyush Narayanan, Lancelot A. Walker, Cesare Russo, Marco di Tullio, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Prague, Czech Republic), July 21 to 25, 2013 Download Citation (BibTeX)
	Monitoring the formation of aneurysms and ruptures in murine aortas using Pulse Wave Imaging (PWI) Sacha D. Nandlall, Monica P. Goldklang, Jeanine M. d'Armiento, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Prague, Czech Republic), July 21 to 25, 2013 Download Citation (BibTeX)
	Monitoring the formation of aneurysms in murine aortas using Pulse Wave Imaging (PWI) Sacha D. Nandlall, Monica P. Goldklang, Jeanine M. d'Armiento, Elisa E. Konofagou American Institute of Ultrasound in Medicine Annual Convention (New York, NY, USA), April 6 to 10, 2013 Download Citation (BibTeX)
	Arterial wall stiffness variations along the canine aorta using pulse wave imaging with validation in vitro Danial Shahmirzadi, Ronny X. Li, William W. Qaqish, Elisa E. Konofagou Biomedical Engineering Society Annual Meeting (Atlanta, GA, USA), October 24 to 27, 2012 Download Full Text (PDF) | Download Citation (BibTeX)
	Pulse Wave Ultrasound Manometry (PWUM) for noninvasive central blood pressure measurement in hypertensive human subjects in vivo Ronny X. Li, Cesare Russo, William W. Qaqish, Marco di Tullio, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Dresden, Germany), October 7 to 10, 2012 Download Citation (BibTeX)
	Performance assessment and optimization of pulse wave imaging for pulse wave analysis in ex vivo canine aortas and in vivo normal human aortas Ronny X. Li, William W. Qaqish, Danial Shahmirzadi, Elisa E. Konofagou 11th International Tissue Elasticity Conference (Deauville, France), October 2 to 5, 2012 Download Citation (BibTeX)
	Effects of the wall inclusion size and modulus contrast on the regional pulse wave propagation along the arterial wall in silico Danial Shahmirzadi, Elisa E. Konofagou 11th International Tissue Elasticity Conference (Deauville, France), October 2 to 5, 2012 Download Full Text (PDF) | Download Citation (BibTeX)
	Performance assessment and optimization of Pulse Wave Imaging (PWI) and its applications for pulse wave analysis in ex vivo canine aortas and in vivo normal human arteries Ronny X. Li, Danial Shahmirzadi, William W. Qaqish, Elisa E. Konofagou 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (San Diego, CA, USA), August 28 to September 1, 2012 Download Citation (BibTeX)
	In vivo pulse wave imaging in the abdominal aortas of hypertensive and aneurysmal human subjects: a feasibility study Ronny X. Li, Jianwen Luo, Lancelot A. Walker, Sherelle Laifer-Narin, Elizabeth Hecht, Farooq A. Chaudhry, Elisa E. Konofagou American Institute of Ultrasound in Medicine Annual Convention (Phoenix, AZ, USA), March 29 to April 1, 2012 Download Citation (BibTeX)
	In vivo pulse wave imaging in the abdominal aortas of hypertensive and aneurysmal human subjects: a feasibility study Ronny X. Li, Jianwen Luo, Tipapon Khamdaeng, Elisa E. Konofagou IEEE International Ultrasonics Symposium (Orlando, FL, USA), October 18 to 21, 2011 Download Citation (BibTeX)
	Simulated pulse wave imaging for local stiffness estimation of patient-specific aorta Danial Shahmirzadi, Ronny X. Li, Jianwen Luo, Elisa E. Konofagou 10th International Tissue Elasticity Conference (Arlington, TX, USA), October 12 to 15, 2011 Download Full Text (PDF) | Download Citation (BibTeX)
	Aortic stiffness estimation via pulse wave imaging in patient-specific simulated and silicone phantom Danial Shahmirzadi, Ronny X. Li, Elisa E. Konofagou Biomedical Engineering Society Annual Meeting (Hartford, CT, USA), October 12 to 15, 2011 Download Full Text (PDF) | Download Citation (BibTeX)
	In-vivo application of pulse wave imaging for arterial stiffness measurement under normal and pathological conditions Ronny X. Li, Jianwen Luo, Sandhya K. Balaram, Farooq A. Chaudhry, J. C. Lantis, Danial Shahmirzadi, Elisa E. Konofagou 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Boston, MA, USA), August 30 to September 3, 2011 Download Citation (BibTeX)
	Simultaneous imaging of cardiovascular wall motion and flow velocity in the heart and vessels of mice in vivo Jianwen Luo, Elisa E. Konofagou American Institute of Ultrasound in Medicine Annual Convention (New York, NY, USA), April 14 to 17, 2011 Download Citation (BibTeX)
	Simultaneous imaging of wall motion and flow velocity in the hearts and vessels of mice in vivo: a feasibility study Jianwen Luo, Elisa E. Konofagou IEEE International Symposium on Biomedical Imaging (Chicago, IL, USA), March 30 to April 2, 2011 Download Citation (BibTeX)
	Internal indentation for direct modulus estimation Jonathan Vappou, Elisa E. Konofagou 9th International Tissue Elasticity Conference (Snowbird, UT, USA), October 16 to 19, 2010 Download Citation (BibTeX)
	Imaging of cardiovascular wall-flow coupling in vivo Jianwen Luo, Elisa E. Konofagou 9th International Tissue Elasticity Conference (Snowbird, UT, USA), October 16 to 19, 2010 Download Citation (BibTeX)
	Regional measurement of arterial stiffness using pulse wave imaging: phantom validation and preliminary clinical results Jonathan Vappou, Jianwen Luo, Elisa E. Konofagou IEEE International Ultrasonics Symposium (San Diego, CA, USA), October 11 to 14, 2010 Download Citation (BibTeX)
	A fast high-performance motion and strain imaging method Jianwen Luo, Elisa E. Konofagou IEEE International Ultrasonics Symposium (San Diego, CA, USA), October 11 to 14, 2010 Download Citation (BibTeX)
	A real-time high-quality radio frequency-based speckle-tracking method Jianwen Luo, Elisa E. Konofagou American Institute of Ultrasound in Medicine Annual Convention (San Diego, CA, USA), March 24 to 27, 2010 Download Citation (BibTeX)
	Validation of Pulse Wave Imaging (PWI) as a quantitative method for mapping arterial elasticity Jonathan Vappou, Jianwen Luo, Elisa E. Konofagou 8th International Tissue Elasticity Conference (Vlissingen, Zeeland, The Netherlands), September 14 to 17, 2009 Download Citation (BibTeX)
	Key parameters for precise lateral displacement estimation in ultrasound elastography Jianwen Luo, Elisa E. Konofagou Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Minneapolis, MN, USA), September 2 to 5, 2009 Download Full Text (PDF) | Download Citation (BibTeX)
	Characterization of the stress-strain relationship of the abdominal aortic wall in vivo Asawinee Danpinid, Jianwen Luo, Jonathan Vappou, Pradit Terdtoon, Elisa E. Konofagou Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (Minneapolis, MN, USA), September 2 to 5, 2009 Download Full Text (PDF) | Download Citation (BibTeX)
	Fundamental analysis of lateral displacement estimation quality in ultrasound elastography Jianwen Luo, Elisa E. Konofagou Proceedings of the 6th IEEE International Symposium on Biomedical Imaging (Boston, MA, USA), July 1 to June 28, 2009 Download Full Text (PDF) | Download Citation (BibTeX)
	Noninvasive imaging of pulse wave propagation and assessment of wall properties in human abdominal aortas in vivo Jianwen Luo, Wei-Ning Lee, Shougang Wang, Elisa E. Konofagou American Institute of Ultrasound in Medicine Annual Convention (New York, NY, USA), April 2 to 5, 2009 Download Citation (BibTeX)
	Pulse wave imaging of human abdominal aortas in vivo Jianwen Luo, Wei-Ning Lee, Shougang Wang, Elisa E. Konofagou Proceedings of the IEEE International Ultrasonics Symposium (Beijing, China), November 2 to 5, 2008 Download Full Text (PDF) | Download Citation (BibTeX)
	Pulse Wave Imaging (PWI) as a tool for the quantitative assessment of vascular elasticity: evaluation of a quantitative finitie-element model and in-vivo results in human subjects Jonathan Vappou, Jianwen Luo, Elisa E. Konofagou 7th International Tissue Elasticity Conference (Austin, TX, USA), October 27 to 30, 2008 Download Citation (BibTeX)
	Finite element modeling of the pulse wave propagation in the aorta for simulation of the Pulse Wave Imaging (PWI) method Jonathan Vappou, Ioannis K. Zervantonakis, Jianwen Luo, Elisa E. Konofagou Proceedings of the 11th International Conference on Medical Image Computing and Computer Assisted Intervention (New York, NY, USA), September 6 to 10, 2008 Download Full Text (PDF) | Download Citation (BibTeX)
	Pulse wave imaging of normal and aneurysmal abdominal aortas in vivo Jianwen Luo, Kana Fujikura, Leslie S. Tyrie, M. David Tilson III, Ioannis K. Zervantonakis, Jonathan Vappou, Elisa E. Konofagou 33rd International Symposium on Ultrasonic Imaging and Tissue Characterization (Arlington, VA, USA), May 14 to 16, 2008 Download Citation (BibTeX)
	Non-invasive imaging of the aortic pulse-wave propagation for the detection of abdominal aortic aneurysms in vivo Kana Fujikura, Jianwen Luo, Leslie S. Tyrie, M. David Tilson III, Elisa E. Konofagou American Heart Association Scientific Sessions (Orlando, FL, USA), November 4 to 7, 2007 Download Citation (BibTeX)
	Imaging of the propagation of the contraction wave using RF-based speckle tracking in vivo Elisa E. Konofagou, Jianwen Luo, Deepak Saluja, Kana Fujikura, Daniel O. Cervantes, James Coromilas American Heart Association Scientific Sessions (Orlando, FL, USA), November 4 to 7, 2007 Download Citation (BibTeX)
	Pulse wave imaging of normal and aneurysmal abdominal aortas in vivo Jianwen Luo, Kana Fujikura, Leslie S. Tyrie, M. David Tilson III, Elisa E. Konofagou 6th International Tissue Elasticity Conference (Santa Fe, NM, USA), November 2 to 5, 2007 Download Citation (BibTeX)
	Pulse wave imaging of abdominal aortic aneurysms: comparison between control and angiotensin II-treated mice in vivo Jianwen Luo, Kana Fujikura, Leslie S. Tyrie, M. David Tilson III, Elisa E. Konofagou Proceedings of the IEEE International Ultrasonics Symposium (New York, NY, USA), October 28 to 31, 2007 Download Full Text (PDF) | Download Citation (BibTeX)
	A non-invasive imaging technique for characterization of vascular mechanical properties in vivo and detection of disease Kana Fujikura, Jianwen Luo, Viktor Gamarnik, Mathieu Pernot, Royd Fukumoto, Shunichi Homma, M. David Tilson III, Elisa E. Konofagou American Institute of Ultrasound in Medicine Annual Convention (New York, NY, USA), March 15 to 8, 2007 Download Citation (BibTeX)
	Pulse wave imaging in murine abdominal aortas: a feasibility study Kana Fujikura, Jianwen Luo, Elisa E. Konofagou Proceedings of the IEEE International Ultrasonics Symposium (Vancouver, BC, Canada), October 2 to 5, 2006 Download Full Text (PDF) | Download Citation (BibTeX)
	Ultrasonic elastography of the mouse aorta: possible usefulness in non-invasive analysis of aortic dilation in mice and risk of rupture in humans Elisa E. Konofagou 10th Anniversary Symposium on the Abdominal Aortic Aneurysm: Genetics, Pathophysiology, and Molecular Biology (New York, NY, USA), April 3 to 5, 2006 Invited Contribution Download Citation (BibTeX)

The researchers involved in this project are listed below.

Principal Investigator

Elisa Konofagou, Ph.D. Email: ek2191 [at] columbia [dot] edu Phone: +1 212 342 0863 Office: PS19-418A View Profile | View Publications

Postdoctoral Research Scientists

	Sacha Nandlall, D.Phil. Email: sn2480 [at] columbia [dot] edu Phone: +1 212 342 1611 Office: PS19-405 View Profile | View Publications
	Danial Shahmirzadi, Ph.D. Email: ds3031 [at] columbia [dot] edu Phone: +1 212 342 1611 Office: PS19-405 View Profile | View Publications

Ph.D. Student

Ronny Li, M.S. Email: rxl2103 [at] columbia [dot] edu Phone: +1 212 342 1611 Office: PS19-405 View Profile | View Publications

Interns

	Isaac Jourard, B.ASc. Email: ij2170 [at] columbia [dot] edu Phone: +1 212 342 1612 Office: PS19-407 View Profile | View Publications
	Prathyush Narayanan, M.S. Email: pn2248 [at] columbia [dot] edu Phone: +1 212 342 1612 Office: PS19-407 View Profile | View Publications
	Joyce Salomon, B.Eng. Email: jks2188 [at] columbia [dot] edu Phone: +1 212 342 1612 Office: PS19-407 View Profile | View Publications