Brenda Chen

3rd year PhD Student

Columbia University
Department of Biomedical Engineering
New York, NY 10027
Phone: (212) 854-5780
email: bc2288(at)columbia(dot)edu

I am currently studying the relationship between cortical brain activity and local changes in blood flow using optical imaging techniques designed and built by our lab. I use camera-based imaging of optical intrinsic signals and two photon microscopy to capture both vascular dynamics and cortical cell activity in-vivo.


2009: MS, Biomedical Engineering, Columbia University, New York, NY
2007: BS, Bioengineering, Cornell University, Ithaca, NY

Professional Experience

2007-present: Graduate research assistant, Laboratory for Functional Optical Imaging, Columbia University. Advisor: Elizabeth Hillman

  1. 2005-2007: Research assistant, Schaffer Group, Biomedical Engineering, Cornell University.
    Advisor: Chris Schaffer

    2006: Summer Research Intern Analytical Chemistry, Amgen, Thousand Oaks, California

    2004-2006: Research assistant, Neuromuscular Biomechanics Lab, Cornell University.
    Advisor: Francisco Valero-Cuevas

Honors and Awards

2009: NSF Graduate student Fellowship
2009: CIMIT Prize for Primary Health Care Finalist


Bouchard M. B*, Chen B. R*, Burgess S. A, Hillman E. M. C, "Ultra-fast multispectral optical imaging of cortical oxygenation, blood flow and intracellular calcium dynamics", Optics Express, 17 (18), 15670-15678, (2009). * Equal contribution first authors.

Radosevich A. J, Bouchard M. B, Burgess S. A, Chen B. R, Hillman E. M. C. "Hyper-spectral in-vivo two-photon microscopy of intrinsic ", Optics Letters, 33 (18), 2164-2166, (2008).

Hillman E. M. C, Burgess S. A, Chen B. "Macroscopic molecular optical imaging of rodent brain" , Book Chapter in "Molecular Imaging of the Rodent Brain" (Neuromethods Series), Editor. Bacskai B. J, Ed. In
press 2008, Human Press (Springer).

Poster Presentations

Chen B. R, Burgess S. A, Radosevich A. J, Bouchard M. B, Cauli B., Hillman E.M.C, Multi-scale in-vivo optical imaging of Neurovascular Coupling.  Gordon Research Conference: Brain Energy Metabolism & Blood Flow.  Andover, New Hampshire, August 2008.

Chen BR, Bouchard MB, McCaslin AFH, Hillman EMC, Characterization of cortical vascular compartment-specific hemodynamics during somatosensory stimulation. Society for Neuroscience Annual Meeting, October 2009, Chicago IL.