Hillman Lab: Biomedical Engineering: Columbia University: Elizabeth Hillman

Elizabeth M. C. Hillman Associate Professor of Biomedical Engineering Columbia University Department of Biomedical Engineering 351 Engineering Terrace 1210 Amsterdam Ave New York, NY 10027 Phone: 212 854 2788 Fax: 212 854 8725 email: eh2245@columbia.edu
Education 1998: BSc & MSc, Physics, University College London, London, UK 2002: Ph.D. Medical Physics and Bioengineering, University College London, London, UK
Academic Positions 2005-6: Instructor, Massachusetts General Hospital (Radiology), Harvard Medical School, Boston, MA 2006-2011 : Assistant Professor, Biomedical Engineering, Columbia University, New York, NY 2006-2011 : Assistant Professor, Radiology, Columbia University Medical Center, New York, NY 2008- : Mentor, Columbia University Graduate Program in Neurobiology and Behavior 2011- : Associate Professor of Biomedical Engineering, Columbia University, New York, NY 2011- : Associate Professor, Radiology, Columbia University Medical Center, New York, NY
Professional and Research Positions 2002-3: Manager of In Vivo Spectroscopy, Argose Inc., Waltham, MA 2003-5: Post-doctoral Research Fellow, Martinos Center for Biomedical Imaging (Radiology), Massachusetts General Hospital, Boston, MA
Professional Affiliations Optical Society of America (OSA) The International Society for Optical Engineering (SPIE) Society for Neuroscience (SFN) International Society for Cerebral Blood Flow and Metabolism (ISCBFM)
Honors and Awards Wood and Oliver Lodge undergraduate awards from University College London (1994-8) Wellcome Trust Prize Studentship, Ph.D. Fellowship (1998-2002) Wallace H Coulter Foundation Early Career Award (2006) Human Frontier of Science Program Young Investigator Award (2007) Rodriguez Junior Faculty Award, Columbia SEAS (2008). Chair of Tissue Imaging and Spectroscopy Technical Group, Optical Society of America (2008-11) NSF CAREER Award (2010) Kavli Institute for Neuroscience at Columbia University Member (2011) 2011 Adolph Lomb Medal, Optical Society of America award for contributions to optics under age 35 Outstanding Short Paper Award, Rank Prize Fund symposium on applications of fast low-level light detection (2000) , Poster Award, Gordon Research Conference: Lasers in Medicine and Biology 2000, Travel Awards for OSA BIOMED 2000, 2006, Gordon Conference LMB 2000, SPIE Photonics West 2001, Gordon Conference (Brain blood flow and metabolism) 2004, Brain'05 2005.
Grant Review and Editorial Service L'Agence Nationale de la Recherche, France North Carolina Biotechnology Center W. M. Keck Foundation Israel Science Foundation Health Research Council of New Zealand NIH: ZEB1 OSR-A M1 S: "New Ways to Image Neural Activity" 2006 NIH: ZRG1 BST-M (50) R: "Nanotechnology" 2007 NIH: BMIT: "Biomedical Imaging Technology" 2007 NIH: SBMI : "Small Business Medical Imaging" 2009 NIH: ZEB1 OSR-C(J2), NIBIB R13 conference grant panel 2011 NIH: NCRR P41 Site Visit 2011 NIH: NIDA Cutting-Edge Basic Research Awards R21 panel. Brain Peer Review Committee, the American Heart Association 2009, 2012 Associate Editor, IEEE Engineering in Medicine and Biology Society Annual Meeting 2008- Special Issue Editor, Applied Optics: "Topics in Biomedical Optics 2008" Review Editor, Frontiers in Neuroenergetics Journal 2008- Topical Editor, Applied Optics (Biomedical Optics) 2009-2011 Special Issue Editor, Biomedical Optics Express 2010 Associate Editor, Biomedical Optics Express 2010- Editorial Board Member, Journal of Biophotonics (Wiley) 2012- Editorial Board Member, Biomedical Spectroscopy and Imaging Journal (IOS Press) 2012-
Conference Service (selected) Program Committee, SPIE Optics East 2005 & 2006 Optical Methods in Drug Discovery and Development Session Chair "Optics in Neuroscience" and Program Committee for National Institute of Health Fifth Inter-Institute Workshop on Optical Diagnostic Imaging from Bench to Bedside, 2006 Session Chair "Imaging brain function & disease", Lasers in Medicine & Biology Gordon Conference, 2006 Session Track Co-Chair, "Diagnostic Instrumentation & Physiological Measurements", IEEE Engineering in Medicine and Biology Conference 2006 Program Chair "Diffuse optical imaging and tomography", OSA BIOMED 2008 Associate Editor, "Biomedical Imaging and Image Processing" IEEE Engineering in Medicine and Biology Society Annual Meeting 2008-2011 Co-Chair "New Optical Instrumentation", World Molecular Imaging Congress 2008 Program Committee, IEEE Lasers and Electro-Optics Society (LEOS) Annual Meeting 2008 Program Committee, European Conference on Biomedical Optics 2009 Program Committee, "Neurons and Photons" conference at SPIE Photonics West 2009 Session Track Co-Chair, "Neural Engineering" IEEE Engineering in Medicine and Biology 2009 Session Chair, "In vivo optical imaging of animal disease models", Engineering Conferences International 2009. Session Chair "Brain" and Program Committee for SPIE NIH Inter-Institute Workshop on Optical Diagnostic and Biophotonic Methods from Bench to Bedside, 2009 Co-Chair, Royal Society Conference "Making light work: Illuminating the future of biomedical optics" 2010 Program Chair "Biological and Drug Discovery Imaging", OSA BIOMED 2010 Chair of Engineering Conferences International (ECI)"Advances in Optics for Biotechnology, Medicine and Surgery XI" meeting 2011 Program Committee, SPIE "Optogenetics and hybrid-optical control of cells" meeting 2013 Co-Chair, Neurophotonics sub-conference at the OSA/SPIE European Conference on Biomedical Optics (ECBO 2013).
Grant Support National Institute of Neurological Disorders and Stroke (NINDS) - PI (R21 & 2 x R01) NSF CAREER Award - PI Wallace H Coulter Foundation - PI (Young Investigator) Human Frontiers Science Program - PI (Young Investigator) National Eye Institute Co-PI (R01) Department of Defense, Army Research Office (MURI contract co-investigator) National Heart, Blood and Lung Institute (NHLBI) - subcontract Co-PI National Institute of Biomedical Imaging and BioEngineering (NIBIB) - Phase I SBIR National Cancer Institute (NCI) - U54 imaging core National Institute of Arthritis, Musculoskeletal and Skin (NIAMS) - P30 imaging core Defense Advanced Research Projects Agency (DARPA) - Phase I SBIR contractor Mentored Students Graduate Fellowships, NSF (4), NDSEG/ONR (1), BioIGERT (2), T32 Medical Scientist Training Program (3)
Publications Hillman E. M. C, PhD Thesis (2002), Download Kozberg M, Chen BR, De Leo SE, Bouchard MB, Hillman EMC, "Resolving the transition from negative to positive BOLD in the developing brain", PNAS, online ahead of print (2013). Amoozegar CB, Wang T, Bouchard MB, McCaslin AFH, Blaner WS, Levenson RM, Hillman EMC, "Dynamic contrast enhanced optical imaging of in-vivo organ function", J Biomed Opt, 17(9), 096003 (2012). Grosberg LE, Chen BR, Hillman EMC, "Simultaneous multi-plane in-vivo non-linear microscopy using spectral encoding", Optics Letters, 37(14), 2967-2969 (2012). . Muldoon, TJ, Burgess SA, Chen BR, Ratner D, and Hillman EMC, "Analysis of skin lesions using laminar optical tomography". Biomed. Opt. Express, 3(7): p. 1701-1712 (2012).. Qiu J, Baik AD, Lu L, Hillman EMC, Zhuang Z, Dong C, Guo XE, “Theoretical Analysis of Novel Quasi-3D Microscopy of Cell Deformation”, Cel. Mol. Bioeng, 5 (2), 165-172. Hillman EMC, Elson DS, Bigio IJ, Levenson RM, So PTC, “Advances in optics for biotechnology, medicine and surgery”, Biomed. Opt. Expr, 3 (3), pp. 531-532 (2012). Hillman EMC, Amoozegar CB, Wang T, McCaslin AFH, Bouchard MB, Mansfield JR, Levenson RM, “In-vivo optical imaging and dynamic contrast methods for biomedical research” Phil. Trans. Royal Soc A. 369 (1955), 4620-4643 (2011).. Chen L, Chan TH, Choyke PL, Hillman EMC, Bhu-jwalla ZM, Chi CY, Wang G, Szabo Z, Wang, Y, “A Signal Deconvolution Tool for In Vivo Dynamic Contrast-enhanced Imaging of Complex Tissues”, Bioinformatics, in press (2011). Grosberg LE, Radosevich AJ, Asfaha S, Yang X, Wang TJ, Hillman EMC, "Spectral characterization and unmixing of intrinsic contrast in intact normal and diseased gastric tissues using hyperspectral two-photon microscopy" PlosOne, 6(5): e19925 (2011). McCaslin AFH, Chen BR, Radosevich AJ, Cauli B, Hillman EMC, "In-vivo 3D morphology of astrocyte-vasculature interactions in the somatosensory cortex: implications for neurovascular coupling", J Cereb Blood Flow Metab, 31, 795-806 (Feature and Cover article) (2011). Chen BR, Bouchard MB, McCaslin AFH, Burgess SA, Hillman EMC, "High-speed vascular dynamics of the hemodynamic response", Neuroimage, 54 (2), 1021-1030 (2011). Baik AD, Lu XL, Qiu J, Huo B, Hillman EMC, Dong C, Guo XE, "Quasi-3D Cytoskeletal Dynamics of Osteocytes under Fluid Flow", Biophys J. 99 (9), 2812-2820 (2010). Taber KH, Hillman EMC, Hurley RA, "Optical Imaging: A New Window to the Adult Brain", Neuropsychiatry Clin Neurosci. 22 (4), 357-360 (2010). (cover) Nordstrom RJ, Almutairi A, Hillman EMC, "Feature Issue Introduction: Bio-Optics in Clinical Applications, Nanotechnology, and Drug Discovery", Biomed Opt Expr, 1 (3) 746-747 (2010). Burgess SA, Ratner D, Chen BR, Hillman EMC, "Fiber-Optic and Articulating Arm Implementations of Laminar Optical Tomography for Clinical Applications" Biomed Opt Expr, 1 (3), 780-790, (2010). Sun R, Bouchard MB, Hillman EMC "SPLASSH: Open source software for camera-based high-speed, multispectral in-vivo optical image acquisition" Biomed Opt Expr, 1 (2), 385-397 (2010). Tian P, Teng IC, May LD, Kurz R, Lu K, Scadeng M, Hillman EMC, De Crespigny AJ, D'Arceuil HE, Mandeville JB, Marota JJA, Rosen BR, Liu TT, Boas DA, Buxton R, Dale AM, Devor A, "Cortical depth-specific microvascular dilation underlies laminar differences in BOLD fMRI response", PNAS, 107 (34), 15246-15251 (2010). Sirotin Y. B, Hillman E. M. C, Bordier C, Das A. "Spatiotemporal precision and hemodynamic mechanism of optical point-spreads in alert primates", PNAS 106, 18390-18395, (2009). Burgess S. A and Hillman E. M. C, "Laminar Optical Tomography", Chapter in 'Handbook of Biomedical Optics'. Eds: Boas DA, Pitris C, Ramanujam N (Taylor & Francis). in press (2009) Bouchard M. B., Chen B. R, Burgess S. A, Hillman E. M. C, "Ultra-fast multispectral optical imaging of cortical oxygenation, blood flow and intracellular calcium dynamics", Optics Express, 17 (18), 15670-15678, (2009). Hillman E. M. C, Burgess S. A, Chen B. “Macroscopic molecular optical imaging of rodent brain”, Book Chapter in ‘Molecular Imaging of the Rodent Brain’ (Neuromethods Series), Editor. Bacskai B. J, Ed. In press 2009, Human Press (Springer). Blaner WS, O’Byrne SM, Wongsiriroj N, Kluwe J, D’Ambrosio D, Jiang H, Schwabe RF, Hillman E.M.C, Piantedosi R, Libien J. “Hepatic Stellate Cell Lipid Droplets: A Specialized Lipid Droplet for Retinoid Storage”, Biochimica et Biophysica Acta, 1791(6):467-73 (2009). Yuan B, Burgess SA, Iranmahboob AK, Bouchard MB, Lehrer N, Bordier C, Hillman EMC, "System for rapid, simultaneous, high resolution, depth-resolved fluorescence and absorption optical imaging", Rev. Sci. Instrum. 80, 043706-1 (2009). Karagiannis A, Gallopin T, David C, Battaglia D, Geoffroy H, Rossier J, Hillman E.M.C, Staiger J, Cauli B. “Classification of NPY-expressing neocortical interneurons", J. Neurosci, 29(11):3642-3659 (2009). Hillman E. M. C, Burgess S. A. "Sub-millimeter Resolution 3D Optical Imaging of Living Tissue using Laminar Optical Tomography", Laser & Photonics Reviews, 3 (1-2), 159-180, (2009). Devor A, Hillman E. M. C, Tian P, Waeber C, Teng I. C, Ruvinskaya S, Shalinsky M, Zhu H, Haslinger R, Narayanan S, Ulbert I, Dunn A. K, Lo E, Rosen B. R, Dale A. M, Kleinfeld D, Boas D. A, “Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex", J. Neurosci, 28: 14347-14357 (2008). Burgess S. A, Bouchard M. B, Yuan B, Hillman E. M. C. “Simultaneous Multi-Wavelength Laminar Optical Tomography"Optics Letters, 33 (22), 2710-2712 (2008). Radosevich A. J, Bouchard M. B, Burgess S. A, Chen B. R, Hillman E. M. C. “Hyper-spectral in-vivo two-photon microscopy of intrinsic fluorophores”, Optics Letters, 33 (18), 2164-2166, (2008).Also selected to appear in the Virtual Journal of Biomedical Optics, 3 (11), 2164 (cover) and the Virtual Journal of Biological Physics Research Hillman E. M. C* and Moore A, "All-optical anatomical coregistration for small animal molecular imaging using dynamic contrast", Nature Photonics, 1 (9), 526 - 530, (2007). Hillman E. M. C, Bernus O, Pease E, Bouchard M. B. Pertsov A. “Depth-resolved optical imaging of transmural electrical propagation in perfused heart”, Optics Express, 15 (26), 17827-17841, (2007). Hillman E. M. C, "Optical Brain Imaging In-vivo: Techniques and Applications from Animal to Man" [Invited Review], J Biomed Opt, 12(5), 051402 (2007). Also selected to appear in the “Virtual Journal of Biological Physics Research” Hillman E. M. C, Devor A, Bouchard M. B, Dunn A. K, Krauss G. W, Skoch J, Bacskai B. J, Dale A. M, Boas D. A, “Depth-resolved Optical Imaging and Microscopy of Vascular C ompartment Dynamics During Somatosensory Stimulation”, NeuroImage, 35(1): 89-104 (2007) '>Supplementary Data. Devor A, Tian P, Nishimura N, Teng IC, Hillman E. M. C, Narayanan S. N, Ulbert I, Boas D. A, Kleinfeld D, Dale A. M.“Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative BOLD”, J Neurosci, 27(16): 4452-4459. (2007) Supplementary Data Custo A, Wells W. M, Barnett A. H, Hillman E. M. C, Boas D. A,"Effective Scattering Coefficient of the Cerebral Spinal Fluid in Adult Head Models for Diffuse O ptical Imaging", Appl Opt. 45(19): 4747-4755 (2006). Zhang Q, Brukilacchio T. J, Li A, Stott J. J, Chaves T, Hillman E. M. C, Wu T, Chorlton M. A, Rafferty E, Moore R. H, Kopans D. B, Boas D. A., "Co-registere d Tomographic X-ray and Optical Breast Imaging: Initial Results." J Biomed Opt, 10(2), 024033-1-9 (2005). Corlu A, Choe R, Durduran T, Lee K, Schweiger M, Arridge S. R, Hillman E. M. C, Yodh A. G., "Diffuse optical tomography with spectral constraints and wavelength opt imization." Appl Opt, 44(11), 2082-2093 (2005) Li A, Boverman G, Zhang Y, Brooks D, Miller E. L, Kilmer M. E, Zhang Q, Hillman E. M. C, Boas D. A., "An optimal linear inverse solution given multiple priors in diffuse optical tomography." Appl Opt, 44(10), 1948-1956 (2005) Hillman, E. M. C, Boas, D. A, Dale, A. M, Dunn, A. K, "Laminar Optical Tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media" Optics Letters, 29, (14), 1650-1652 (2004). Hillman, E. M. C, "Optical tomography", Book chapter in 'Optics Encyclopedia', Wiley-VCH. (Released December 2003). Corlu, A, Durduran, T, Choe, R, Schweiger, M, Hillman, E. M. C, Arridge, S. R. Yodh, A. G,>"Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography” Optics Letters, 28, 23, 2339-2341 (2003). Hebden, J. C, Gonzalez, F. M, Gibson, A, Hillman, E. M. C, Yusof, R, Everdell, N, Delpy, D. T, Zaccanti, G, and Martelli, F, “Assessment of an in situ temporal calibration method for time-resolved optical tomography” Journal of Biomedical Optics 8, 87-92 (2003). Hebden,J. C, Gibson, A, Yusof, R, Everdell, N, Hillman, E. M. C, Delpy, D. T, Arridge, S. R, Austin, T, Meek, J. H, Wyatt, J. S, "Three-dimensional optical tomography of the premature infant brain” Phys. Med. Biol , 47, 23, 4155-4166 (2002). Hebden, J. C, Veenstra, H, Dehghani, H, Hillman, E. M. C,* Schweiger, M, Arridge, S. R, nd Delpy, D. T , '>"Three dimensional time-resolved optical tomogr aphy of a conical breast phantom" Applied Optics 40 19, 3278-3287 (2001). Hillman, E. M. C, Hebden, J. C, Schweiger, M, Dehghani, H, Schmidt, F. E. W, Delpy, D. T, Arridge, S. R "Time Resolved Optical Tomography of the Human Forearm" Phys. Med. Biol, 46, 4, 1117-1130 (2001) Hillman,E.M.C, Hebden,J.C, Schmidt,F.E.W, Arridge,S.R, Schweiger,M, Dehghani,H, Delpy, D.T "Calibration techniques and datatype extraction for time-resolved op tical tomography" Rev Sci Instrum, 71, 9, 3415-3427 (2000). Schmidt, F. E. W, Hebden, J. C, Hillman, E. M. C, Fry ,M. E, Schweiger,M, Delpy,D. T "Multiple slice imaging of a tissue-equivalent phantom using time-resolved op tical tomography" Applied Optics 39, 19 3380-3387 (2000). Arridge, S. R., Hebden, J. C, Schweiger, M, Schmidt, FEW, Fry, M. E. Hillman, E. M. C, Dehghani,H "A method for 3D time-resolved optical tomography"A method for 3D time-resolved optical tomography" Imaging. Syst. Technol, 11, 2-11 (2000). Schmidt, F.E.W, Fry, M.E, Hillman, E.M.C, Hebden, J.C, and Delpy, D.T "A 32-channel time-resolved instrument for medical optical tomography" R ev. Sci. Instrum 71, 1, 256 - 265 (2000). Hebden, J.C, Schmidt, F.E.W, Fry, M.E, Schweiger, M, Hillman, E.M.C, Delpy, D.T, and Arridge, S. R "Simultaneous reconstruction of absorption and scatter ing images using multi-channel measurement of purely temporal data" Optics Letters, 24, 8, 534-536. (1999). Elwell, C.E, Springett, R, Hillman, E.M.C, Delpy,D.T "Oscillations in Cerebral Haemodynamics - Implications for Functional Activation Studies". Adv. Exp Med & Biol 471, 57-65 (1999). . .