Research Overview

Our research focuses on capturing functional information about living tissues using optical techniques. A major theme of our lab is in-vivo neuroimaging, in particular examination of the relationship between blood flow changes in the brain and underlying neuronal activity. This work has led us to develop a range of advanced in-vivo imaging technologies including laminar optical tomography and hyperspectral two-photon microscopy. We are exploring additional applications for these technologies including clinical and pre-clinical imaging of living skin. We are also developing techniques for non-invasive 'molecular imaging' of small animals to allow improved studies of disease and development of new treatments and drugs. The sections below provide more details about our projects and imaging technologies.

Neuroimaging & Neurovascular coupling

 

Using advanced optical, in-vivo imaging and microscopy techniques to understand the relationship between neuronal activity and blood flow in the intact brain. Learn More

   
Imaging Technology

We custom build all of our imaging systems and software. Look here to find descriptions of our camera, LOT, L-SIPT and dual-beam two-photon microscope designs, as well as for downloads of our free software. Learn More

   
Molecular Imaging

Small animal molecular imaging allows researchers and drug companies to follow disease and treatment response in a single mouse. We have developed a technique that allows improved imaging by exploiting the temporal dynamics of injected fluorescent dyes. Learn More

   
Skin Imaging  

Optical imaging is well-suited to skin imaging applications, since light does not need to penetrate very deeply into the tissue to yeild useful information. We are exploring the utility of a range of optical imaging and spectroscopy techniques for clinical and pre-clinical skin imaging. Learn More

   
Cardiac Imaging  
Cardiac

Fluorescent voltage sensitive dyes allow imaging of rapid changes in membrane potential in cardiac tissue. We are developing a range of approaches for functional imaging of both perfused intact hearts and engineered cardiac tissues. Learn More

   
Light Propagation  

Modeling is an essential part of optical imaging, since light scattering and absorption will always affect measurements. We predominantly develop and use Monte Carlo models of light propagation for both quantitative spectroscopy and 3D image reconstruction. Learn More

   
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