Cells have the remarkable ability to respond to complex features of the extracellular environment. Our laboratory focuses on how cells recognize such signals, leading to both fundamental understanding of cells as microscale machines and strategies for directing cellular function. Current studies examine how the micro-/nano-scale dynamics of protein presentation, including lateral mobility along cellular membranes and resistance to mechanical forces, drive intracellular signaling. In addition, we are investigating how cells integrate multiple cues of the extracellular environment for intracellular signaling.
This research is supported by the National Institutes of Health, the National Science Foundation, the Wallace H. Coulter Foundation, and the Irving Institute for Clinical and Translational Research.
For more information, please contact:
Lance Kam, Ph.D.
Department of Biomedical Engineering, Columbia University