Peer-Reviewed Full Length Original Research Publications


  • Qu D, Subramony SD, Boskey AL, Pleshko N, Doty SB and Lu HH; "Compositional mapping of the mature anterior cruciate ligament-to-bone insertio", Journal of Orthopaedic Research, Epub ahead of print, 2017. (link)
  • Lee NM, Erisken C, Iskratsch T, Sheetz M, Levine WN and Lu HH; "Polymer fiber-based models of connective tissue repair and healing", Biomaterials, 112(2017):303-12, 2017. (pdf)
  • Qu D, Chuang PJ, Prateepchinda SP, Balasubramanian PS, Yao X, Doty SB, Hendon CP and Lu HH; "Micro- and ultrastructural characterization of age-related changes at the anterior cruciate ligament-to-bone insertion", ACS Biomaterials Science & Engineering, Epub ahead of print, 2016. (link)
  • Wang IE, Bogdanowicz DR, Mitroo S, Shan J, Kala S and Lu HH; "Cellular interactions regulate stem cell differentiation in tri-culture", Connective Tissue Research, Epub ahead of print, 2016. (link)
  • Khanarian NT, Boushell MK, Spalazzi JP, Pleshko N, Boskey AL and Lu HH; "FTIR-I compositional mapping of the cartilage-to-bone interface as a function of tissue region and age", Journal of Bone and Mineral Research, 29(12):2643-52, 2014. (pdf)
  • Subramony SD, Su A, Yeager K and Lu HH; "Combined effects of chemical priming and mechanical stimulation on mesenchymal stem cell differentiation on nanofiber scaffolds", Journal of Biomechanics, 47(9):2189-96, 2014. (pdf)


  • Spalazzi JP, Boskey A, Camacho N and Lu HH; "Characterization of matrix and mineral content at the anterior cruciate ligament-to-bone insertion sites", PLoS ONE, 8(9):e74349, 2013. (pdf)
  • Subramony SD, Dargis BR, Castillo M, Azeloglu EU, Tracey MS, Su A and Lu HH; "Biomaterial alignment and mechanical stimulation guide stem cell differentiation", Biomaterials, 34(8):1942-53, 2013. (pdf)
  • Erisken CE, Zhang X, Moffat KL, Levine WN and Lu HH; "Scaffold fiber diameter regulates human tendon fibroblast growth and differentiation", Tissue Engineering, 19(3-4):519-28, 2013. (pdf)
  • Khanarian NT, Haney NM, Burga RA and Lu HH; “A functional agarose-hydroxyapatite scaffold for osteochondral interface regeneration”, Biomaterials, 33:5247-58, 2012. (pdf)
  • Khanarian NT, Jiang J, Wan LQ, Mow VC and Lu HH; “A hydrogel-mineral composite scaffold for osteochondral interface tissue engineering”, Tissue Engineering Part A, 18(5-6):533-45, 2012. (pdf)
  • Wan LQ, Jiang J, Miller DE, Guo XE, Mow VC and Lu HH; “Matrix deposition modulates the viscoelastic shear properties of hydrogel-based cartilage grafts”, Tissue Engineering Part A, 17(7-8):1111-22, 2011. (pdf)
  • Jiang J, Tang A, Ateshian GA, Guo XE, Hung CT and Lu HH; “Bioactive stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repair”, Annals of Biomedical Engineering, 38(6):2183-96, 2010. (pdf)
  • Chan ME, Lu XL, Huo B, Baik AD, Chiang V, Guldberg RE, Lu HH and Guo XE; “A trabecular bone explant model of osteocyte-osteoblast co-culture for bone mechanobiology”, Cellular and Molecular Bioengineering, 2(3):405-15, 2009. (pdf)
  • Moffat KL, Kwei AS, Spalazzi JP, Doty SB, Levine WN and Lu HH; “Novel nanofiber-based scaffold for rotator cuff repair and augmentation”, Tissue Engineering Part A, 15(1):115-26, 2009. (pdf)
  • Lu HH, Vo JM, Lin J, Shin S, Cozin M, Tsay R and Landesberg R; “Controlled delivery of growth factors derived from platelet-rich plasma for bone formation”, Journal of Biomedical Materials Research A, 86A(4):1128-36, 2008. (pdf)
  • Spalazzi JP, Vyner MC, Jacobs MT, Moffat KL, Rich CG and Lu HH; “Mechano-active scaffold induces tendon remodeling and expression of fibrocartilage markers”, Clinical Orthopaedics and Related Research, 466(8):1938-48, 2008. (pdf)
  • Moffat KL, Sun WA, Pena PE, Chahine NO, Doty SB, Ateshian GA, Hung CT, and Lu HH; “Characterization of the structure-function relationship at the ligament-to-bone interface”, Proceedings of the National Academy of Sciences, 105(23): 7947-72, 2008. (pdf)
  • Spalazzi JP, Dagher E, Doty SB, Guo XE, Rodeo SA and Lu HH; “In vivo evaluation of multi-phased scaffold designed for orthopaedic interface tissue engineering and soft tissue-to-bone integration”, Journal of Biomedical Materials Research A86A(1): 1-12, 2008. (pdf)
  • Wan LQ, Jiang J, Arnold DE, Hurst WJ, Guo XE, Lu HH and Mow VC, “Calcium concentration effects on the mechanical and biochemical properties of chondrocyte-alginate constructs”, Cellular and Molecular Bioengineering, 1(1):93-102, 2008. (pdf)
  • Jiang J, Leong NL, Mung J, Hidaka C and Lu HH; “Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP”, Osteoarthritis and Cartilage, 16(1):70-82, 2008. (pdf)
  • Wang IE, Shan M, Chen FH and Lu HH; “Role of osteoblast-fibroblast interactions in the regeneration of the ligament-to-bone interface”, Journal of Orthopaedic Research, 25(12):1609-20, 2007. (pdf)
  • Chao PG, Nicoll SB, Bulinski JC, Lu HH and Hung CT, “Effects of applied DC electric field on ligament fibroblast migration and wound healing”, Connective Tissue Research, 48(4):188-97, 2007. (pdf)


  • Spalazzi JP, Doty SB, Moffat KL, Levine WN and Lu HH; “Development of controlled matrix heterogeneity on a triphasic scaffold for orthopedic interface tissue engineering”, Tissue Engineering, 12(12):3497-508, 2006. (pdf)
  • Spalazzi JP, Gallina J, Fung-Kee-Fung SD, Konofagou EE and Lu HH; “Elastographic imaging of strain distributions within the anterior cruciate ligament and at the ligament-to-bone insertion”, Journal of Orthopedic Research, 24(10):2001-10, 2006. (pdf)
  • Wang IE, Mitroo S, Chen FH, Lu HH and Doty SB; “Age-dependent changes in matrix composition and organization at the ligament-to-bone insertion”, Journal of Orthopedic Research, 24(8):1745-55, 2006. (pdf)
  • Jiang J, Nicoll SB and Lu HH; “Co-culture of osteoblasts and chondrocytes modulates cellular differentiation in vitro”, Biochemical and Biophysical Research Communications, 338:762-70, 2005. (pdf)
  • Lu HH, Tang A, Oh S, Spalazzi JP and Dionisio K; “Compositional effects on the formation of a calcium phosphate layer and the response osteoblast-like cells on polymer-bioactive glass composites”, Biomaterials, 26(32):6323-34, 2005. (pdf)
  • Landesberg R, Burke A, Pinsky D, Katz R, Vo J, Eisig SB and Lu HH; “Activation of platelet rich plasma using thrombin receptor agonist peptide”, Journal of Oral and Maxillofacial Surgery, 63:529-35, 2005. (pdf)
  • Tsay RC, Vo J, Burke A, Eisig SB, Lu HH and Landesberg R; “Differential growth factor retention by platelet-rich plasma composites”, Journal of Oral and Maxillofacial Surgery, 63:521-28, 2005. (pdf)
  • Lu HH, Cooper JA, Manuel S, Freeman JW, Attawia M.A., Ko FK and Laurencin CT; “Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studies”, Biomaterials, 26(23):4805-16, 2005. (pdf)
  • Cooper JA, Lu HH, Ko FK and Laurencin CT; “Fiber-based, tissue engineered scaffold for ligament replacement: design considerations and in vitro evaluations”, Biomaterials, 26(13):1523-32, 2005. (pdf)
  • Lu HH, Jiang J, Tang A, Hung CT and Guo XE; “Development of controlled heterogeneity on a polymer-ceramic hydrogel scaffold for osteochondral repair”, Key Engineering Materials (Bioceramics 17), 17:607-10, 2005.
  • El-Amin SF, Kofron MD, Attawia MA, Lu HH, Tuan RS and Laurencin CT; “Molecular regulation of osteoblasts for tissue engineered bone repair”, Clinical Orthopedics, Oct(427):220-25, 2004. (pdf)
  • Spalazzi JP, Dionisio KL, Jiang J and Lu HH; “Matrix and substrate-dependent effects on osteoblast and chondrocyte interactions during co-culture”, EMBS Magazine-Special Issue in Tissue Engineering, 21(5):104-111, 2003. (pdf)
  • Hung CT, Lima EG, Mauck RL, LeRoux MA, Lu HH, Stark RG, Guo XE and Ateshian GA; “Anatomically shaped osteochondral constructs for articular cartilage repair”, Journal of Biomechanics, 36:1853-64, 2003. (pdf)
  • Lu HH, Kofron MD, El-Amin SF, Attawia MA and Laurencin CT; “In vitro bone formation using muscle-derived cells: a new paradigm for bone tissue engineering”, Biochemical and Biophysical Research Communications, 305:882-89, 2003. (pdf)
  • Altman GH, Lu HH, Horan RL, Calabro T, Ryder D, Kaplan DL, Stark P, Martin I, Richmond JC and Vunjak-Novakovic G; “Advanced bioreactor with controlled application of multi-dimensional strain for tissue engineering”, Journal of Biomechanical Engineering, 124:742-49, 2003. (pdf)
  • Lu HH, Scott K, El-Amin SF and Laurencin CT; “Three-dimensional, bioactive, biodegradable polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization by human osteoblast-like cells in vitro”, Journal of Biomedical Materials Research, 64A:465-74,2003. (pdf)
  • El-Amin SF, Lu HH, Khan Y, Burems J, Mitchell J, Tuan RS and Laurencin CT; “Extracellular matrix production by human osteoblasts cultured on biodegradable polymers applicable for tissue engineering”. Biomaterials, 24(7):1213-21, 2003. (pdf)
  • Altman GH, Lu HH, Horan R, Moreau J, Martin I, Richmond J and Kaplan DL; “Silk matrix for tissue engineered anterior cruciate ligaments”, Biomaterials, 23(20):4131-41, 2002. (pdf)
  • El-Amin SF, Attawia M, Lu HH, Shah AK, Chang R, Hickok N, Tuan RS and Laurencin CT; “Human osteoblast integrin expression on degradable polymeric materials for tissue engineered bone”, Journal of Orthopaedic Research, 20(1):20-28, 2002. (pdf)


  • Laurencin CT, Attawia MA, Borden MD, Lu HH, Gorum WJ and Lieberman J; “Poly(lactide-co-glycolide)/hydroxyapatite delivery of BMP-2-producing cells: a regional gene therapy approach to bone regeneration”, Biomaterials, 22(11):1271-77, 2001. (pdf)
  • Lu HH, Pollack SR and Ducheyne P; “45S5 bioactive glass zeta potential variations and the formation kinetics of a glass surface calcium phosphate layer in a fibronectin-containing solution”, Journal of Biomedical Materials and Research, 54:455-462, 2001. (pdf)
  • Lu HH, Pollack SR and Ducheyne P; “Temporal zeta potential variations of 45S5 bioactive glass immersed in an electrolyte solution”, Journal of Biomedical Materials and Research, 51:80-87, 2000. (pdf)