> RESEARCH
Polymer-Ceramic Composites for Orthopaedic Tissue Engineering
We are also pursuing the development of polymer-ceramic/bioactive glass composites and the design of three-dimensional scaffold based on these novel composite materials. Specifically, we seek to balance changes in scaffold mechanical properties with biodegradability and desired bioactivity, in addition to elucidating the mechanism behind the bioactivity or osteo-integration potential of these composites. Current studies focus on evaluating the effects of scaffold fabrication and culturing parameters on the phenotype and genotype of stem cells and differentiated connective tissue cells cultured on the composite scaffolds in vitro and in vivo.
Related Publications
- Lu HH, Scott K, El-Amin SF and Laurencin CT; “Three-dimensional, bioactive, biodegradable polymer-bioactive glass composite scaffolds with improved mechanical properties support collagen synthesis and mineralization by human osteoblast-like cells in vitro”, Journal of Biomedical Materials Research, 64A:465-474,2003.
- Lu HH, Cooper JA, Manuel S, Freeman JW, Attawia M.A., Ko FK and Laurencin CT; “Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studies”, Biomaterials, 26(23):4805-4816, 2005.
- Lu HH, Tang A, Oh S, Spalazzi JP and Dionisio K; “Compositional effects on the formation of a calcium phosphate layer and the response osteoblast-like cells on polymer-bioactive glass composites”, Biomaterials, 26(32):6323-6334, 2005.
- Wan LQ, Jiang J, Arnold DE, Hurst WJ, Guo XE, Lu HH and Mow VC, “Calcium concentration effects on the mechanical and biochemical properties of chondrocyte-alginate constructs”, Cellular and Molecular Bioengineering, 1(1):93-102, 2008.