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Orthopaedic Interface Tissue Engineering

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Overview of Interface Tissue Engineering

  • Mikos AG, Herring SW, Ochareon P, Elisseeff J, Lu HH, Kandel R, Schoen FJ, Toner M, Mooney D, Atala A, Van Dyke ME, Kaplan D, Vunjak-Novakovic G, “Engineering Complex Tissues”, Tissue Engineering, 12(12):3307-3339, 2006.
  • Lu HH and Jiang JJ, Interface Tissue Engineering and the Formulation of Multiple-Tissue Systems, Advances in Biochemical Engineering and Biotechnology, 102:91-111, (Special Volume: Tissue Engineering, Lee K and Kaplan DL eds., Springer Verlag, New York), 2006.
  • Moffat KL, Wang IE, Rodeo SA and Lu HH; “Orthopaedic interface tissue engineering for the biological fixation of soft tissue grafts”, Clinics in Sports Medicine, 28(1):15-76.
  • Lu HH and Spalazzi JP; “Biomimetic stratified scaffold design for ligament-to-bone interface tissue engineering”, Special Issue of Combinatorial Chemistry & High Throughput Screening, In Press.

Interface Structure-Function Relationship

  • Wang IE, Mitroo S, Chen FH, Lu HH* and Doty SB; “Age-dependent changes in matrix composition and organization at the ligament-to-bone insertion”, Journal of Orthopedic Research, 24(8):1745-1755, 2006.
  • Spalazzi JP, Gallina J, Fung-Kee-Fung SD, Konofagou EE and Lu HH; “Elastographic Imaging of Strain Distributions within the Anterior Cruciate Ligament and at the Ligament-to-Bone Insertion”, Journal of Orthopedic Research, 24(10):2001-2010, 2006.
  • Moffat KL, Sun WA, Pena PE, Chahine NO, Doty SB, Ateshian GA, Hung CT, and Lu HH; “Characterization of the structure-function relationship at the ligament-to-bone interface”, Proceedings of the National Academic of Sciences, 105(23): 7947-7952, 2008.

Mechanism of Interface Regeneration and Homeostasis - Role of Cellular Interactions

  • Spalazzi JP, Dionisio KL, Jiang J and Lu HH; “Matrix and substrate-dependent effects on osteoblast and chondrocyte interactions during co-culture”, EMBS Magazine-Special Issue in Tissue Engineering, 21(5):104-111, 2003.
  • Jiang J, Nicoll SB and Lu HH; “Co-culture of osteoblasts and chondrocytes modulates cellular differentiation in vitro”, Biochemical and Biophysical Research Communications, 338:762-770, 2005.
  • Wang IE, Shan J, Choi R, Oh S, Kepler CK, Chen FH and Lu HH; “Role of Osteoblast-Fibroblast Interactions in the Formation of the Ligament-to-Bone Interface”, Journal of Orthopaedic Research, 25(12):1609-1620, 2007.
  • Jiang J, Leong NL, Mung J, Hidaka C and Lu HH; “Interaction between zonal populations of articular chondrocytes suppresses chondrocyte mineralization and this process is mediated by PTHrP”, Osteoarthritis and Cartilage, 16(1):70-82, 2008.

Biomimetic Scaffold Design for the Formation of Complex Tissues

  • Lu HH, Jiang J, Tang A, Hung CT and Guo XE; “Development of controlled heterogeneity on a polymer-ceramic hydrogel scaffold for osteochondral repair”, Key Engineering Materials (Bioceramics 17), 17:607-610, 2005.
  • Spalazzi JP, Doty SB, Moffat KL, Levine WN and Lu HH; “Development of Controlled Matrix Heterogeneity on a Triphasic Scaffold for Orthopedic Interface Tissue Engineering”, Tissue Engineering, 12(12):3497-3508, 2006.
  • Spalazzi JP, Dagher E, Doty SB, Guo XE, Rodeo SA and Lu HH; “In vivo evaluation of multi-phased scaffold designed for orthopaedic interface tissue engineering and soft tissue-to-bone integration”, Journal of Biomedical Materials Research A, 86A(1): 1-12, 2008.
  • Spalazzi JP, Vyner MC, Jacobs MT, Moffat KL, Rich CG and Lu HH; “Mechano-active scaffold induces tendon remodeling and expression of fibrocartilage markers”, Clinical Orthopaedics and Related Research, 466(8):1938-1948, 2008.
  • Moffat KL, Spalazzi JP, Doty SB, Levine WN and Lu HH; “Novel nanofiber based scaffold for rotator cuff repair and augmentation”, Tissue Engineering, In Press.